Localization of the insulin-binding site to the cysteine-rich region of the insulin receptor alpha-subunit.
about
Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinityThe role of insulin receptor sulphydryl groups in insulin binding and cellular response in rat adipocytesFive mutant alleles of the insulin receptor gene in patients with genetic forms of insulin resistance.Developmental regulation of the rat insulin-like growth factor I receptor gene.Functionally distinct insulin receptors generated by tissue-specific alternative splicing.Three-dimensional structural interactions of insulin and its receptor.High-affinity insulin binding to an atypical insulin-like growth factor-I receptor in human breast cancer cells.Cloning of cDNA for the alpha subunit of mouse insulin-like growth factor I receptor and the role of the receptor in metanephric developmentThe ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site.A region of the insulin receptor important for ligand binding (residues 450-601) is recognized by patients' autoimmune antibodies and inhibitory monoclonal antibodies.The insulin receptor changes conformation in unforeseen ways on ligand binding: sharpening the picture of insulin receptor activation.Expression and characterization of a 70-kDa fragment of the insulin receptor that binds insulin. Minimizing ligand binding domain of the insulin receptor.Fusion of insulin receptor ectodomains to immunoglobulin constant domains reproduces high-affinity insulin binding in vitro.A leucine-to-proline mutation in the insulin receptor in a family with insulin resistance.Molecular defects of insulin/IGF-1 receptor transmembrane signaling.Congenital insulin resistance associated with a conformational alteration in a conserved beta-sheet in the insulin receptor L1 domain.Inhibitory effect of fluoride on insulin receptor autophosphorylation and tyrosine kinase activityDecoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains.Deletion of lysine 121 creates a temperature-sensitive alteration in insulin binding by the insulin receptor.An Insulin Receptor Mutant (Asp707→ Ala), Involved in Leprechaunism, Is Processed and Transported to the Cell Surface but Unable to Bind Insulin
P2860
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P2860
Localization of the insulin-binding site to the cysteine-rich region of the insulin receptor alpha-subunit.
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年学术文章
@wuu
1988年学术文章
@zh
1988年学术文章
@zh-cn
1988年学术文章
@zh-hans
1988年学术文章
@zh-my
1988年学术文章
@zh-sg
1988年學術文章
@yue
1988年學術文章
@zh-hant
name
Localization of the insulin-bi ...... nsulin receptor alpha-subunit.
@en
Localization of the insulin-bi ...... nsulin receptor alpha-subunit.
@nl
type
label
Localization of the insulin-bi ...... nsulin receptor alpha-subunit.
@en
Localization of the insulin-bi ...... nsulin receptor alpha-subunit.
@nl
prefLabel
Localization of the insulin-bi ...... nsulin receptor alpha-subunit.
@en
Localization of the insulin-bi ...... nsulin receptor alpha-subunit.
@nl
P2093
P1476
Localization of the insulin-bi ...... nsulin receptor alpha-subunit.
@en
P2093
P304
P356
10.1016/S0006-291X(88)80050-0
P407
P577
1988-11-01T00:00:00Z