Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase. - Wikidata - wikimedia - TriplyDB

Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase.

Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase.

http://www.wikidata.org/entity/Q45057145

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The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevis The stomatin-like protein SLP-1 and Cdk2 interact with the F-Box protein Fbw7-γ The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7 Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1 Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17 MicroRNA-223 regulates cyclin E activity by modulating expression of F-box and WD-40 domain protein 7 Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis Towards the computational design of protein post-translational regulation Dysregulation of ubiquitin ligases in cancer Constitutive turnover of cyclin E by Cul3 maintains quiescence The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation The next level of complexity: crosstalk of posttranslational modifications.The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4.Pathogenic bacteria target NEDD8-conjugated cullins to hijack host-cell signaling pathways Ras activity regulates cyclin E degradation by the Fbw7 pathway.The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy.Notch-dependent expression of the archipelago ubiquitin ligase subunit in the Drosophila eye.C. elegans Dicer interacts with the P-granule component GLH-1 and both regulate germline RNPs Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3.Fbw7 repression by hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions.Developmental downregulation of Xenopus cyclin E is phosphorylation and nuclear import dependent and is mediated by ubiquitination.DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3 Fbw7/hCDC4 dimerization regulates its substrate interactions Dysregulation of zinc finger protein, X-linked (ZFX) impairs cell proliferation and induces apoptosis in human oral squamous cell carcinorma.SCF-mediated protein degradation and cell cycle control.Fbw7γ-mediated degradation of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes.FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors Stringent Control of NFE2L3 (Nuclear Factor, Erythroid 2-Like 3; NRF3) Protein Degradation by FBW7 (F-box/WD Repeat-containing Protein 7) and Glycogen Synthase Kinase 3 (GSK3).DEC1 regulates breast cancer cell proliferation by stabilizing cyclin E protein and delays the progression of cell cycle S phase.p53 negatively regulates Aurora A via both transcriptional and posttranslational regulation.Proline-mediated proteasomal degradation of the prostate-specific tumor suppressor NKX3.1.E3 Ubiquitin Ligase Fbw7 Negatively Regulates Osteoblast Differentiation by Targeting Runx2 for Degradation.SEL-10/Fbw7-dependent negative feedback regulation of LIN-45/Braf signaling in C. elegans via a conserved phosphodegron.FBXW7 is involved in Aurora B degradation.Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system.The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7 Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo.

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P2860

Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase.

http://www.wikidata.org/entity/Q45057145

description

2004 nî lūn-bûn

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2004年の論文

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2004年学术文章

@wuu

2004年学术文章

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2004年学术文章

@zh-cn

2004年学术文章

@zh-hans

2004年学术文章

@zh-my

2004年学术文章

@zh-sg

2004年學術文章

@yue

2004年學術文章

@zh-hant

name

Recognition of phosphodegron motifs in human cyclin E by the SCF

@nl

Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase.

@en

type

label

Recognition of phosphodegron motifs in human cyclin E by the SCF

@nl

Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase.

@en

prefLabel

Recognition of phosphodegron motifs in human cyclin E by the SCF

@nl

Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase.

@en

P1433

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P1433

Journal of Biological Chemistry

P1476

Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase.

@en

P2093

Bruce E Clurman

http://www.w3.org/2001/XMLSchema#string

Eric Spooner

http://www.w3.org/2001/XMLSchema#string

J Wade Harper

http://www.w3.org/2001/XMLSchema#string

Jun Qin

http://www.w3.org/2001/XMLSchema#string

Stephen J Elledge

http://www.w3.org/2001/XMLSchema#string

Xin Ye

http://www.w3.org/2001/XMLSchema#string

P2860

Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

Identification of a family of human F-box proteins

A family of mammalian F-box proteins

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

P304

50110-50119

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P31

scholarly article

P356

10.1074/JBC.M409226200

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P407

P433

48

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P478

279

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P50

Grzegorz Nalepa

Benedikt M. Kessler

P577

2004-09-13T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

15364936

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