EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism. - Wikidata - wikimedia - TriplyDB

EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism.

EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism.

http://www.wikidata.org/entity/Q45265258

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Redox-directed cancer therapeutics: molecular mechanisms and opportunities Novel curcumin- and emodin-related compounds identified by in silico 2D/3D conformer screening induce apoptosis in tumor cells In vivo and in vitro suppression of hepatocellular carcinoma by EF24, a curcumin analog Identification of T. gondii myosin light chain-1 as a direct target of TachypleginA-2, a small-molecule inhibitor of parasite motility and invasion CLEFMA-an anti-proliferative curcuminoid from structure-activity relationship studies on 3,5-bis(benzylidene)-4-piperidones.Liver S9 Fraction-Derived Metabolites of Curcumin Analogue UBS109.Safe and targeted anticancer efficacy of a novel class of antioxidant-conjugated difluorodiarylidenyl piperidones: differential cytotoxicity in healthy and cancer cells Anticancer efficacy of a difluorodiarylidenyl piperidone (HO-3867) in human ovarian cancer cells and tumor xenografts.Diphenyl difluoroketone: a potent chemotherapy candidate for human hepatocellular carcinoma Autophagy and apoptosis in hepatocellular carcinoma induced by EF25-(GSH)2: a novel curcumin analog.Curcumin improves prostanoid ratio in diabetic mesenteric arteries associated with cyclooxygenase-2 and NF-κB suppression.Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane).Tumor angiogenesis therapy using targeted delivery of Paclitaxel to the vasculature of breast cancer metastases.Perspectives on chemopreventive and therapeutic potential of curcumin analogs in medicinal chemistry.The curcumin analog EF24 targets NF-κB and miRNA-21, and has potent anticancer activity in vitro and in vivo Novel synthetic monoketone transmute radiation-triggered NFκB-dependent TNFα cross-signaling feedback maintained NFκB and favors neuroblastoma regression.Lesson learned from nature for the development of novel anti-cancer agents: implication of isoflavone, curcumin, and their synthetic analogs.Eliminating the heart from the curcumin molecule: monocarbonyl curcumin mimics (MACs).Liposome-encapsulated EF24-HPβCD inclusion complex: a preformulation study and biodistribution in a rat model.Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy.Mouse pharmacokinetics and metabolism of the curcumin analog, 4-piperidinone,3,5-bis[(2-fluorophenyl)methylene]-acetate(3E,5E) (EF-24; NSC 716993).3,5-bis(2,4-difluorobenzylidene)-4-piperidone, a novel compound that affects pancreatic cancer growth and angiogenesis Anticancer activity of an imageable curcuminoid 1-[2-aminoethyl-(6-hydrazinopyridine-3-carbamidyl)-3,5-bis-(2-fluorobenzylidene)-4-piperidone (EFAH)Pleiotropic protective effects of phytochemicals in Alzheimer's disease Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties.EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression Safe and targeted anticancer therapy for ovarian cancer using a novel class of curcumin analogs Activation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1.Synthetic curcumin analog EF31 inhibits the growth of head and neck squamous cell carcinoma xenografts Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin.Chemopreventive potential of natural compounds in head and neck cancer EF24 inhibits tumor growth and metastasis via suppressing NF-kappaB dependent pathways in human cholangiocarcinoma.Synergistic antitumor activity of rapamycin and EF24 via increasing ROS for the treatment of gastric cancer.Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?Curcumin analog cytotoxicity against breast cancer cells: exploitation of a redox-dependent mechanism.Monocarbonyl curcumin analogues: heterocyclic pleiotropic kinase inhibitors that mediate anticancer properties.Stronger proteasomal inhibition and higher CHOP induction are responsible for more effective induction of paraptosis by dimethoxycurcumin than curcumin.Multifaceted roles of curcumin: two sides of a coin!Curcumin and neurodegenerative diseases: a perspective.

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P2860

EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism.

http://www.wikidata.org/entity/Q45265258

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2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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2005年學術文章

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name

EF24, a novel synthetic curcum ...... a a redox-dependent mechanism.

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EF24, a novel synthetic curcum ...... a a redox-dependent mechanism.

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type

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EF24, a novel synthetic curcum ...... a a redox-dependent mechanism.

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EF24, a novel synthetic curcum ...... a a redox-dependent mechanism.

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prefLabel

EF24, a novel synthetic curcum ...... a a redox-dependent mechanism.

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EF24, a novel synthetic curcum ...... a a redox-dependent mechanism.

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Anti-Cancer Drugs

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EF24, a novel synthetic curcum ...... a a redox-dependent mechanism.

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Aiming Sun

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Brian K Adams

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Dean P Jones

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Dennis C Liotta

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Jiyang Cai

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Marike Herold

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Yang J Lu

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