Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA.
about
Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicityInteraction of Huntington disease protein with transcriptional activator Sp1Evolutionary conservation and selection of human disease gene orthologs in the rat and mouse genomesMouse models of polyglutamine diseases: review and data table. Part IMultiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange SyndromeThe chicken or the egg: mitochondrial dysfunction as a cause or consequence of toxicity in Huntington's diseaseInhibition of caspase-1 slows disease progression in a mouse model of Huntington's diseaseHuntingtin and its role in neuronal degenerationNormal huntingtin function: an alternative approach to Huntington's diseaseThe ubiquitin proteasome system in glia and its role in neurodegenerative diseasesCellular localization and development of neuronal intranuclear inclusions in striatal and cortical neurons in R6/2 transgenic miceMutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitroNuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicityA Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in miceMouse models of Huntington's disease and methodological considerations for therapeutic trials.Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease.Intracellular inclusions, pathological markers in diseases caused by expanded polyglutamine tracts?Stem Cells Transplantation and Huntington's DiseaseAre there multiple pathways in the pathogenesis of Huntington's disease?Polyglutamine pathogenesis.Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins.Huntington disease models and human neuropathology: similarities and differencesMutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease miceHuntingtin localisation studies - a technical review.Toward an understanding of polyglutamine neurodegeneration.Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment.RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model.Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell deathOf mice and men: solving the molecular mysteries of Huntington's disease.Protein aggregation and pathogenesis of Huntington's disease: mechanisms and correlations.Juvenile onset Huntington's disease--clinical and research perspectives.Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigsThe selective vulnerability of nerve cells in Huntington's disease.Caspases in Huntington's disease.Allele-selective inhibition of huntingtin expression by switching to an miRNA-like RNAi mechanism.Animal models of Huntington's disease.Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior.Transgenic animal models of neurodegeneration based on human genetic studies.Striatal infusion of glial conditioned medium diminishes huntingtin pathology in r6/1 mice.Clinical and research advances in Huntington's disease.
P2860
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P2860
Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
Behavioural abnormalities and ...... g mutated full-length HD cDNA.
@en
Behavioural abnormalities and ...... g mutated full-length HD cDNA.
@nl
type
label
Behavioural abnormalities and ...... g mutated full-length HD cDNA.
@en
Behavioural abnormalities and ...... g mutated full-length HD cDNA.
@nl
prefLabel
Behavioural abnormalities and ...... g mutated full-length HD cDNA.
@en
Behavioural abnormalities and ...... g mutated full-length HD cDNA.
@nl
P2093
P356
P1433
P1476
Behavioural abnormalities and ...... g mutated full-length HD cDNA.
@en
P2093
L Pike-Buchanan
M Williams
W O Whetsell
P2888
P304
P356
10.1038/2510
P407
P577
1998-10-01T00:00:00Z
P6179
1017619672