Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice.
about
Vimentin is a novel AKT1 target mediating motility and invasionPrdx1 inhibits tumorigenesis via regulating PTEN/AKT activityVEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinasePHLiPPing the switch on Akt and protein kinase C signalingThe kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAsLoss of PHLPP expression in colon cancer: role in proliferation and tumorigenesisNEDD9 promotes oncogenic signaling in mammary tumor development.PI3K and AKT: Unfaithful Partners in CancerKinase AKT controls innate immune cell development and functionRebuilding cancer metastasis in the mousePosttranslational regulation of Akt in human cancerAMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation.Apc mutation enhances PyMT-induced mammary tumorigenesisMaximising the potential of AKT inhibitors as anti-cancer treatmentsTargeting the Phosphatidylinositol-3-kinase Pathway in Gastric Cancer: Can Omics Improve Outcomes?mTOR signaling in tumorigenesisRole of PI3K, mTOR and Akt2 signalling in hepatic tumorigenesis via the control of PKM2 expressionDistinct effects of EGFR ligands on human mammary epithelial cell differentiationRegulation of PI3K effector signalling in cancer by the phosphoinositide phosphatasesA Transformation-Defective Polyomavirus Middle T Antigen with a Novel Defect in PI3 Kinase Signaling.The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migrationVav3 oncogene activates estrogen receptor and its overexpression may be involved in human breast cancer.FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis.BST-2/tetherin is overexpressed in mammary gland and tumor tissues in MMTV-induced mammary cancer.A potential role for intragenic miRNAs on their hosts' interactome.Signaling specificity in the Akt pathway in biology and disease.Novel transcripts from a distinct promoter that encode the full-length AKT1 in human breast cancer cellsSubcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: potential clinical implicationsA genomic analysis of mouse models of breast cancer reveals molecular features of mouse models and relationships to human breast cancer.Distinct roles of the three Akt isoforms in lactogenic differentiation and involution.Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1.Small-molecule inhibitors of the PI3K signaling networkAkt1 deletion prevents lung tumorigenesis by mutant K-ras.Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progressionAkt2 regulates expression of the actin-bundling protein palladinOncogenes and tumor suppressor genesInsulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetesAn allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo.Genetically engineered mouse models of PI3K signaling in breast cancer.Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis
P2860
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P2860
Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Akt1 ablation inhibits, wherea ...... yoma middle T transgenic mice.
@en
Akt1 ablation inhibits, wherea ...... yoma middle T transgenic mice.
@nl
type
label
Akt1 ablation inhibits, wherea ...... yoma middle T transgenic mice.
@en
Akt1 ablation inhibits, wherea ...... yoma middle T transgenic mice.
@nl
prefLabel
Akt1 ablation inhibits, wherea ...... yoma middle T transgenic mice.
@en
Akt1 ablation inhibits, wherea ...... yoma middle T transgenic mice.
@nl
P2093
P1433
P1476
Akt1 ablation inhibits, wherea ...... yoma middle T transgenic mice.
@en
P2093
Ioanna G Maroulakou
Philip N Tsichlis
Stephen P Naber
William Oemler
P304
P356
10.1158/0008-5472.CAN-06-3782
P407
P577
2007-01-01T00:00:00Z