Association of a polymorphism of the phospholipase D2 gene with the prevalence of colorectal cancer. - Wikidata - wikimedia - TriplyDB

Association of a polymorphism of the phospholipase D2 gene with the prevalence of colorectal cancer.

Association of a polymorphism of the phospholipase D2 gene with the prevalence of colorectal cancer.

http://www.wikidata.org/entity/Q45858801

about

Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor Role of the autotaxin-lysophosphatidate axis in cancer resistance to chemotherapy and radiotherapy Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity Two sites of action for PLD2 inhibitors: The enzyme catalytic center and an allosteric, phosphoinositide biding pocket.Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.Positive feedback regulation between phospholipase D and Wnt signaling promotes Wnt-driven anchorage-independent growth of colorectal cancer cells.Phospholipase D2 Enhances Epidermal Growth Factor-Induced Akt Activation in EL4 Lymphoma Cells.Phospholipase D in cell signaling: from a myriad of cell functions to cancer growth and metastasis.Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway.Choline metabolism in malignant transformation.Phospholipase D: enzymology, functionality, and chemical modulation Physiological and pathophysiological roles for phospholipase D.Down-regulation of MicroRNAs (MiRs) 203, 887, 3619 and 182 Prevents Vimentin-triggered, Phospholipase D (PLD)-mediated Cancer Cell Invasion.Serum deprivation confers the MDA-MB-231 breast cancer line with an EGFR/JAK3/PLD2 system that maximizes cancer cell invasion Phospholipase D elevates the level of MDM2 and suppresses DNA damage-induced increases in p53.A Single Nucleotide Polymorphism in the Phospholipase D1 Gene is Associated with Risk of Non-Small Cell Lung Cancer.The transcription factors Slug (SNAI2) and Snail (SNAI1) regulate phospholipase D (PLD) promoter in opposite ways towards cancer cell invasion.Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis.Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells.Temporal production of the signaling lipid phosphatidic acid by phospholipase D2 determines the output of extracellular signal-regulated kinase signaling in cancer cells Phosphatidic acid, phospholipase D and tumorigenesis.Targeting phospholipase D with small-molecule inhibitors as a potential therapeutic approach for cancer metastasis.Phospholipase D (PLD) drives cell invasion, tumor growth and metastasis in a human breast cancer xenograph model.Chemical modulation of glycerolipid signaling and metabolic pathways.Inhibition of phospholipaseD2 increases hypoxia-induced human colon cancer cell apoptosis through inactivating of the PI3K/AKT signaling pathway.Hypoxia-inducible factor 1-alpha up-regulates the expression of phospholipase D2 in colon cancer cells under hypoxic conditions.Targeting Phospholipid Metabolism in Cancer.Targeting phospholipase D in cancer, infection and neurodegenerative disorders.Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells.Alternative phospholipase D/mTOR survival signal in human breast cancer cells.Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity.1,3-disubstituted-4-aminopyrazolo [3, 4-d] pyrimidines, a new class of potent inhibitors for phospholipase D.Phospholipase D and Its Essential Role in Cancer.Pharmacophore modelling, virtual screening and molecular docking studies on PLD1 inhibitors.Fate of Liposomes in the Presence of Phospholipase C and D: From Atomic to Supramolecular Lipid Arrangement

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P2860

Association of a polymorphism of the phospholipase D2 gene with the prevalence of colorectal cancer.

http://www.wikidata.org/entity/Q45858801

description

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Association of a polymorphism ...... evalence of colorectal cancer.

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Association of a polymorphism ...... evalence of colorectal cancer.

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Association of a polymorphism ...... evalence of colorectal cancer.

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Association of a polymorphism ...... evalence of colorectal cancer.

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Association of a polymorphism ...... evalence of colorectal cancer.

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Association of a polymorphism ...... evalence of colorectal cancer.

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S00109-002-0411-X

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Journal of Molecular Medicine

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Association of a polymorphism ...... evalence of colorectal cancer.

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Hiroji Iwata

http://www.w3.org/2001/XMLSchema#string

Hitoshi Yoshida

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Kazuo Tajima

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Masashi Tanaka

http://www.w3.org/2001/XMLSchema#string

Masayuki Shinoda

http://www.w3.org/2001/XMLSchema#string

Motokazu Suyama

http://www.w3.org/2001/XMLSchema#string

Nobuyuki Hamajima

http://www.w3.org/2001/XMLSchema#string

Suzuno Kusakabe

http://www.w3.org/2001/XMLSchema#string

Tetsuya Mitsudomi

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Tomoyuki Kato

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P2860

Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2

Phospholipase D: molecular and cell biology of a novel gene family

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

Signalling roles of mammalian phospholipase D1 and D2.

Regulation and possible role of mammalian phospholipase D in cellular functions.

Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity.

Colorectal carcinogenesis: historical review.

Competitive amplification and unspecific amplification in polymerase chain reaction with confronting two-pair primers.

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colorectal cancer