Analysis of the human factor VIII A2 inhibitor epitope by alanine scanning mutagenesis.
about
The tertiary structure and domain organization of coagulation factor VIIIHigh-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance.Epitope mapping factor VIII A2 domain by affinity-directed mass spectrometry: residues 497-510 and 584-593 comprise a discontinuous epitope for the monoclonal antibody R8B12.Comparison of factor VIII transgenes bioengineered for improved expression in gene therapy of hemophilia ANew-generation recombinant factor concentrates: bridge to gene therapy.Clustered basic residues within segment 484-510 of the factor VIIIa A2 subunit contribute to the catalytic efficiency for factor Xa generation.Haemophilia A: effects of inhibitory antibodies on factor VIII functional interactions and approaches to prevent their action.Optimization of factor VIII replacement therapy: can structural studies help in evading antibody inhibitors?PEGylation of a factor VIII-phosphatidylinositol complex: pharmacokinetics and immunogenicity in hemophilia A mice.Identification of 31 novel mutations in the F8 gene in Spanish hemophilia A patients: structural analysis of 20 missense mutations suggests new intermolecular binding sites.Generation of an optimized lentiviral vector encoding a high-expression factor VIII transgene for gene therapy of hemophilia AHaemophilia therapies.Passive transfer of polyethylene glycol to liposomal-recombinant human FVIII enhances its efficacy in a murine model for hemophilia A.Engineering less immunogenic and antigenic FVIII proteins.T cell recognition of the A2 domain of coagulation factor VIII in hemophilia patients and healthy subjects.Identification of porcine coagulation factor VIII domains responsible for high level expression via enhanced secretion.Molecular Characterization of the Immune Response to Factor VIII
P2860
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P2860
Analysis of the human factor VIII A2 inhibitor epitope by alanine scanning mutagenesis.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Analysis of the human factor VIII A2 inhibitor epitope by alanine scanning mutagenesis.
@en
Analysis of the human factor VIII A2 inhibitor epitope by alanine scanning mutagenesis.
@nl
type
label
Analysis of the human factor VIII A2 inhibitor epitope by alanine scanning mutagenesis.
@en
Analysis of the human factor VIII A2 inhibitor epitope by alanine scanning mutagenesis.
@nl
prefLabel
Analysis of the human factor VIII A2 inhibitor epitope by alanine scanning mutagenesis.
@en
Analysis of the human factor VIII A2 inhibitor epitope by alanine scanning mutagenesis.
@nl
P2093
P2860
P356
P1476
Analysis of the human factor VIII A2 inhibitor epitope by alanine scanning mutagenesis.
@en
P2093
P2860
P304
30191-30195
P356
10.1074/JBC.272.48.30191
P407
P577
1997-11-01T00:00:00Z