Severity of vanishing white matter disease does not correlate with deficits in eIF2B activity or the integrity of eIF2B complexes.
about
Astrocytes are central in the pathomechanisms of vanishing white matterCrystal structure of eukaryotic translation initiation factor 2BPoor cerebral inflammatory response in eIF2B knock-in mice: implications for the aetiology of vanishing white matter diseaseA yeast purification system for human translation initiation factors eIF2 and eIF2Bε and their use in the diagnosis of CACH/VWM diseaseIdentification of residues that underpin interactions within the eukaryotic initiation factor (eIF2) 2B complexInsights into the architecture of the eIF2Bα/β/δ regulatory subcomplexImpaired eukaryotic translation initiation factor 2B activity specifically in oligodendrocytes reproduces the pathology of vanishing white matter disease in mice.Biochemical effects of mutations in the gene encoding the alpha subunit of eukaryotic initiation factor (eIF) 2B associated with Vanishing White Matter diseaseParadoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells.eIF2B promotes eIF5 dissociation from eIF2*GDP to facilitate guanine nucleotide exchange for translation initiation.A new function and complexity for protein translation initiation factor eIF2BArchitecture of the eIF2B regulatory subcomplex and its implications for the regulation of guanine nucleotide exchange on eIF2.Crystal structure of eIF2B and insights into eIF2-eIF2B interactions.Endoplasmic Reticulum Protein Quality Control Failure in Myelin Disorders.Leukodystrophies: a proposed classification system based on pathological changes and pathogenetic mechanisms.Identification of intersubunit domain interactions within eukaryotic initiation factor (eIF) 2B, the nucleotide exchange factor for translation initiation.Proteomic and Metabolomic Analyses of Vanishing White Matter Mouse Astrocytes Reveal Deregulation of ER Functions.EIF2B2 mutations in Vanishing White Matter Disease hyper- suppress translation and delay recovery during the integrated stress response.Role of Saccharomyces cerevisiae TAN1 (tRNA acetyltransferase) in eukaryotic initiation factor 2B (eIF2B)-mediated translation control and stress response.The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes.Identification of variants in pleiotropic genes causing "isolated" premature ovarian insufficiency: implications for medical practice
P2860
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P2860
Severity of vanishing white matter disease does not correlate with deficits in eIF2B activity or the integrity of eIF2B complexes.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh-hant
name
Severity of vanishing white ma ...... integrity of eIF2B complexes.
@en
Severity of vanishing white ma ...... integrity of eIF2B complexes.
@nl
type
label
Severity of vanishing white ma ...... integrity of eIF2B complexes.
@en
Severity of vanishing white ma ...... integrity of eIF2B complexes.
@nl
prefLabel
Severity of vanishing white ma ...... integrity of eIF2B complexes.
@en
Severity of vanishing white ma ...... integrity of eIF2B complexes.
@nl
P2093
P2860
P356
P1433
P1476
Severity of vanishing white ma ...... integrity of eIF2B complexes.
@en
P2093
Carola G M van Berkel
Gert C Scheper
Hannemieke D W van der Lei
Marjo S van der Knaap
Noel C Wortham
Tsitsi Arikana Mufunde
Weida Huang
Xuemin Wang
P2860
P304
P356
10.1002/HUMU.21535
P577
2011-09-01T00:00:00Z