The proto-oncogene product p120(cbl) links c-Src and phosphatidylinositol 3'-kinase to the integrin signaling pathway.
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Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motilityA role for Syk-kinase in the control of the binding cycle of the beta2 integrins (CD11/CD18) in human polymorphonuclear neutrophilsA novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytesFgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophilsAPS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytesThe adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interactionc-Cbl facilitates fibronectin matrix production by v-Abl-transformed NIH3T3 cells via activation of small GTPasesA role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesionsThe CBL-related protein CBLB participates in FLT3 and interleukin-7 receptor signal transduction in pro-B cellsThe Cbl interactome and its functionsFyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cellsCommon genetic denominators for Ca++-based skeleton in Metazoa: role of osteoclast-stimulating factor and of carbonic anhydrase in a calcareous spongeThe Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation.The adapter protein Crkl links Cbl to C3G after integrin ligation and enhances cell migration.Suppression of apoptosis induced by growth factor withdrawal by an oncogenic form of c-Cbl.Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient miceInteraction of c-Cbl with myosin IIA regulates Bleb associated macropinocytosis of Kaposi's sarcoma-associated herpesvirus.Cbl: many adaptations to regulate protein tyrosine kinases.Activated Fes protein tyrosine kinase induces terminal macrophage differentiation of myeloid progenitors (U937 cells) and activation of the transcription factor PU.1.Beyond the RING: CBL proteins as multivalent adapters.Cbl-transforming variants trigger a cascade of molecular alterations that lead to epithelial mesenchymal conversionThe diverse functions of Src family kinases in macrophages.A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration.The integrin beta1 subunit transmembrane domain regulates phosphatidylinositol 3-kinase-dependent tyrosine phosphorylation of Crk-associated substrate.Hck enhances the adherence of lipopolysaccharide-stimulated macrophages via Cbl and phosphatidylinositol 3-kinase.Role of phosphoinositide 3-kinase and the Cbl adaptor protein in coupling the alpha4beta1 integrin to mitogen-activated protein kinase signalling.Leucine zipper-mediated homodimerization of the adaptor protein c-Cbl. A role in c-Cbl's tyrosine phosphorylation and its association with epidermal growth factor receptor.Intracellular movement of green fluorescent protein-tagged phosphatidylinositol 3-kinase in response to growth factor receptor signalingTyrosine phosphorylation of C-Cbl facilitates adhesion and spreading while suppressing anchorage-independent growth of V-Abl-transformed NIH3T3 fibroblasts.Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation.c-Cbl-facilitated cytoskeletal effects in v-Abl-transformed fibroblasts are regulated by membrane association of c-Cbl.Platelet alpha IIb-beta 3 integrin engagement induces the tyrosine phosphorylation of Cbl and its association with phosphoinositide 3-kinase and Syk.Soluble E-selectin induces monocyte chemotaxis through Src family tyrosine kinases.Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor.Alpha6beta1 integrin induces proteasome-mediated cleavage of erbB2 in breast cancer cells.Epigallocatechin gallate, a green tea polyphenol, mediates NO-dependent vasodilation using signaling pathways in vascular endothelium requiring reactive oxygen species and Fyn.
P2860
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P2860
The proto-oncogene product p120(cbl) links c-Src and phosphatidylinositol 3'-kinase to the integrin signaling pathway.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh-hant
name
The proto-oncogene product p120
@nl
The proto-oncogene product p12 ...... he integrin signaling pathway.
@en
type
label
The proto-oncogene product p120
@nl
The proto-oncogene product p12 ...... he integrin signaling pathway.
@en
prefLabel
The proto-oncogene product p120
@nl
The proto-oncogene product p12 ...... he integrin signaling pathway.
@en
P2093
P2860
P356
P1476
The proto-oncogene product p12 ...... he integrin signaling pathway.
@en
P2093
P2860
P304
P356
10.1074/JBC.272.6.3780
P407
P577
1997-02-01T00:00:00Z