Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers.
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Getting in shape: controlling peptide bioactivity and bioavailability using conformational constraintsOxadiazole-Based Cell Permeable Macrocyclic Transition State Inhibitors of Norovirus 3CL ProteaseSynthesis of macrocyclic organo-peptide hybrids from ribosomal polypeptide precursors via CuAAC-/hydrazide-mediated cyclizationRing-Expansion Approach to Medium-Sized Lactams and Analysis of Their Medicinal Lead-Like Properties.A bicyclic peptide scaffold promotes phosphotyrosine mimicry and cellular uptakeHigh-throughput evaluation of relative cell permeability between peptoids and peptides.Encoded combinatorial libraries for the construction of cyclic peptoid microarraysEarly endosomal escape of a cyclic cell-penetrating peptide allows effective cytosolic cargo delivery.On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds.Direct Ras Inhibitors Identified from a Structurally Rigidified Bicyclic Peptide Library.A Cleavable Scaffold Strategy for the Synthesis of One-Bead One-Compound Cyclic Peptoid Libraries That Can Be Sequenced By Tandem Mass Spectrometry.Back to the future: can physical models of passive membrane permeability help reduce drug candidate attrition and move us beyond QSPR?Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansionSynthesis and screening of stereochemically diverse combinatorial libraries of peptide tertiary amides.Concise synthesis and biological assessment of (+)-neopeltolide and a 16-member stereoisomer library of 8,9-dehydroneopeltolide: identification of pharmacophoric elements.Screening bicyclic peptide libraries for protein-protein interaction inhibitors: discovery of a tumor necrosis factor-α antagonistCyclic peptides as therapeutic agents and biochemical tools.Antimicrobial cyclic peptides for plant disease controlPrincipal component analysis as a tool for library design: a case study investigating natural products, brand-name drugs, natural product-like libraries, and drug-like librariesSolid-phase synthesis of diverse peptide tertiary amides by reductive amination.Ribosomal Synthesis of Macrocyclic Peptides in Vitro and in Vivo Mediated by Genetically Encoded Aminothiol Unnatural Amino AcidsSynthesis of a large library of macrocyclic peptides containing multiple and diverse N-alkylated residues.cis-Peptide Bonds: A Key for Intestinal Permeability of Peptides? .Carbohydrates in diversity-oriented synthesis: challenges and opportunities.Anthranilic acid-containing cyclic tetrapeptides: at the crossroads of conformational rigidity and synthetic accessibilityTesting physical models of passive membrane permeation.Strained cyclophane macrocycles: impact of progressive ring size reduction on synthesis and structureCharacterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants.Side-chain-to-tail cyclization of ribosomally derived peptides promoted by aryl and alkyl amino-functionalized unnatural amino acidsDesign of cyclic peptides that bind protein surfaces with antibody-like affinity.Androgen receptor antagonism by divalent ethisterone conjugates in castrate-resistant prostate cancer cells.Beyond cyclosporine A: conformation-dependent passive membrane permeabilities of cyclic peptide natural products.Macrocycles in new drug discovery.Strategic approaches to optimizing peptide ADME propertiesCell-Permeable Peptides Containing Cycloalanine Residues.Rational, computer-enabled peptide drug design: principles, methods, applications and future directions.Cyclic peptide oral bioavailability: Lessons from the past.Peptidyl-Proline Isomerases (PPIases): Targets for Natural Products and Natural Product-Inspired Compounds.Natural and Synthetic Macrocyclic Inhibitors of the Histone Deacetylase Enzymes.Restriction of the conformational dynamics of the cyclic acyldepsipeptide antibiotics improves their antibacterial activity.
P2860
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P2860
Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Testing the conformational hyp ...... cyclic peptide diastereomers.
@en
Testing the conformational hyp ...... cyclic peptide diastereomers.
@nl
type
label
Testing the conformational hyp ...... cyclic peptide diastereomers.
@en
Testing the conformational hyp ...... cyclic peptide diastereomers.
@nl
prefLabel
Testing the conformational hyp ...... cyclic peptide diastereomers.
@en
Testing the conformational hyp ...... cyclic peptide diastereomers.
@nl
P2093
P356
P1476
Testing the conformational hyp ...... cyclic peptide diastereomers.
@en
P2093
Glenn L Millhauser
R Scott Lokey
Taha Rezai
P304
P356
10.1021/JA0563455
P407
P577
2006-03-01T00:00:00Z