In vivo effects of cytokines on pancreatic beta-cells in models of type I diabetes dependent on CD4(+) T lymphocytes.
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Bioluminescence imaging reveals dynamics of beta cell loss in the non-obese diabetic (NOD) mouse modelGranzyme B is dispensable in the development of diabetes in non-obese diabetic mice.CD4 T cells mediate cardiac xenograft rejection via host MHC Class IIPathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease.In vivo diabetogenic action of CD4+ T lymphocytes requires Fas expression and is independent of IL-1 and IL-18.IFN-γ receptor deficiency prevents diabetes induction by diabetogenic CD4+, but not CD8+, T cellsThe role of perforin and granzymes in diabetes.Neutralization Versus Reinforcement of Proinflammatory Cytokines to Arrest Autoimmunity in Type 1 Diabetes.An indirect role for NK cells in a CD4(+) T-cell-dependent mouse model of type I diabetes.Perforin facilitates beta cell killing and regulates autoreactive CD8+ T-cell responses to antigen in mouse models of type 1 diabetes.Fas/Fas-Ligand Interaction As a Mechanism of Immune Homeostasis and β-Cell Cytotoxicity: Enforcement Rather Than Neutralization for Treatment of Type 1 Diabetes.Mouse pancreatic beta cells express MHC class II and stimulate CD4(+) T cells to proliferate.Autoreactive T cells induce necrosis and not BCL-2-regulated or death receptor-mediated apoptosis or RIPK3-dependent necroptosis of transplanted islets in a mouse model of type 1 diabetes.
P2860
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P2860
In vivo effects of cytokines on pancreatic beta-cells in models of type I diabetes dependent on CD4(+) T lymphocytes.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
In vivo effects of cytokines o ...... pe I diabetes dependent on CD4
@nl
In vivo effects of cytokines o ...... ndent on CD4(+) T lymphocytes.
@en
type
label
In vivo effects of cytokines o ...... pe I diabetes dependent on CD4
@nl
In vivo effects of cytokines o ...... ndent on CD4(+) T lymphocytes.
@en
prefLabel
In vivo effects of cytokines o ...... pe I diabetes dependent on CD4
@nl
In vivo effects of cytokines o ...... ndent on CD4(+) T lymphocytes.
@en
P2093
P2860
P356
P1476
In vivo effects of cytokines o ...... ndent on CD4(+) T lymphocytes.
@en
P2093
Eveline Angstetra
Helen E Thomas
Janette Allison
Kate L Graham
Nadine L Dudek
Pere Santamaria
Rima Darwiche
Rochelle Ayala-Perez
Sarah Emmett
Thomas W H Kay
P2860
P2888
P304
P356
10.1038/ICB.2008.81
P577
2008-11-18T00:00:00Z
P5875
P6179
1015565203