Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice
about
Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.Interactions between the microbiota and the immune systemStructural and functional characterization of a single-chain peptide-MHC molecule that modulates both naive and activated CD8+ T cellsIdd9.1 locus controls the suppressive activity of FoxP3+CD4+CD25+ regulatory T-cellsInsulin as a key autoantigen in the development of type 1 diabetesRole of autoreactive CD8+ T cells in organ-specific autoimmune diseases: insight from transgenic mouse models.Transgenes and knockout mutations in animal models of type 1 diabetes and multiple sclerosis.Mouse Models for Type 1 Diabetes.Matrix metalloproteinases, T cell homing and beta-cell mass in type 1 diabetes.Developmental control of CD8 T cell-avidity maturation in autoimmune diabetes.Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic miceInterleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.In situ recognition of autoantigen as an essential gatekeeper in autoimmune CD8+ T cell inflammationIL-1alpha, IL-1beta, and IFN-gamma mark beta cells for Fas-dependent destruction by diabetogenic CD4(+) T lymphocytesThe pathogenicity of self-antigen decreases at high levels of autoantigenicity: a computational approach.Compensatory mechanisms allow undersized anchor-deficient class I MHC ligands to mediate pathogenic autoreactive T cell responsesGranzyme B is dispensable in the development of diabetes in non-obese diabetic mice.RAG-dependent peripheral T cell receptor diversification in CD8+ T lymphocytesIL-18 is required for self-reactive T cell expansion in NOD mice.Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral bloodThymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice.Specificity of peptide selection by antigen-presenting cells homozygous or heterozygous for expression of class II MHC molecules: The lack of competitionIntracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.High-throughput sequencing of islet-infiltrating memory CD4+ T cells reveals a similar pattern of TCR Vβ usage in prediabetic and diabetic NOD miceGABA exerts protective and regenerative effects on islet beta cells and reverses diabetesRotavirus activates lymphocytes from non-obese diabetic mice by triggering toll-like receptor 7 signaling and interferon production in plasmacytoid dendritic cellsThe programmed death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivoA pancreatic beta-cell-specific homolog of glucose-6-phosphatase emerges as a major target of cell-mediated autoimmunity in diabetesResponses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.Therapeutic regulatory T cells subvert effector T cell function in inflamed islets to halt autoimmune diabetes.Cross-differentiation from the CD8 lineage to CD4 T cells in the gut-associated microenvironment with a nonessential role of microbiotaEvaluation of immunosuppressive function of regulatory T cells using a novel in vitro cytotoxicity assayBeta cells cannot directly prime diabetogenic CD8 T cells in nonobese diabetic mice.Prevalent CD8(+) T cell response against one peptide/MHC complex in autoimmune diabetes.Development of new strategies to prevent type 1 diabetes: the role of animal models.Acute and chronic animal models for the evaluation of anti-diabetic agents.Germline TRAV5D-4 T-cell receptor sequence targets a primary insulin peptide of NOD mice.Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity.Gut microbiota amplifies host-intrinsic conversion from the CD8 T cell lineage to CD4 T cells for induction of mucosal immune tolerance.The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice
P2860
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P2860
Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice
@ast
Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice
@en
type
label
Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice
@ast
Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice
@en
prefLabel
Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice
@ast
Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice
@en
P2093
P2860
P356
P1476
Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice
@en
P2093
Anderson B
Santamaria P
Verdaguer J
P2860
P304
P356
10.1084/JEM.186.10.1663
P407
P577
1997-11-01T00:00:00Z