Chemical genetics: where genetics and pharmacology meet.
about
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2The chemical biology of protein phosphorylationKinases as druggable targets in trypanosomatid protozoan parasitesTargeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitorsBivalent inhibitors of protein kinasesProtein lysine acetylation by p300/CBPMolecular characterization of heterogeneous mesenchymal stem cells with single-cell transcriptomesInhibition of O-GlcNAcase Using a Potent and Cell-Permeable Inhibitor Does Not Induce Insulin Resistance in 3T3-L1 AdipocytesA chemical genomics study identifies Snf1 as a repressor of GCN4 translationDesign, synthesis, and characterization of a highly effective Hog1 inhibitor: a powerful tool for analyzing MAP kinase signaling in yeastA positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeastConversion of a Single Polypharmacological Agent into Selective Bivalent Inhibitors of Intracellular Kinase ActivityLight-controlled modulation of gene expression by chemical optoepigenetic probesRNA Polymerase II C-Terminal Domain: Tethering Transcription to Transcript and TemplateNetwork Architecture Predisposes an Enzyme to Either Pharmacologic or Genetic Targeting.Novel Phenotypic Fluorescent Three-Dimensional Platforms for High-throughput Drug Screening and Personalized Chemotherapy.Mitotic catenation is monitored and resolved by a PKCε-regulated pathwayMyosin-Vb functions as a dynamic tether for peripheral endocytic compartments during transferrin trafficking.The chemokine receptor antagonist, TAK-779, decreased experimental autoimmune encephalomyelitis by reducing inflammatory cell migration into the central nervous system, without affecting T cell function.Targeting the cancer kinome through polypharmacology.DNA ligases: progress and prospects.Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity.Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsiosesCyclic AMP sensor EPAC proteins and energy homeostasis.Human lung cancer cells grown in an ex vivo 3D lung model produce matrix metalloproteinases not produced in 2D cultureExpedient construction of small molecule macroarrays via sequential palladium- and copper-mediated reactions and their ex situ biological testing.Target identification and mechanism of action in chemical biology and drug discovery.A whole-organism screen identifies new regulators of fat storage.Organic synthesis toward small-molecule probes and drugs.Identification, in vitro activity and mode of action of phosphoinositide-dependent-1 kinase inhibitors as antifungal moleculesChemical genomics for studying parasite gene function and interaction.Tampering with cell division by using small-molecule inhibitors of CDK-CKS protein interactions.Structure-guided design of a methyl donor cofactor that controls a viral histone H3 lysine 27 methyltransferase activityMycobacterium tuberculosis lacking all mycolic acid cyclopropanation is viable but highly attenuated and hyperinflammatory in miceCapturing cell-fate decisions from the molecular signatures of a receptor-dependent signaling response.A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development.Ligand binding to the AMP-activated protein kinase active site mediates protection of the activation loop from dephosphorylationAnalysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells.Inhibition of DYRK1A Stimulates Human β-Cell ProliferationTFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast
P2860
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P2860
Chemical genetics: where genetics and pharmacology meet.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Chemical genetics: where genetics and pharmacology meet.
@en
Chemical genetics: where genetics and pharmacology meet.
@nl
type
label
Chemical genetics: where genetics and pharmacology meet.
@en
Chemical genetics: where genetics and pharmacology meet.
@nl
prefLabel
Chemical genetics: where genetics and pharmacology meet.
@en
Chemical genetics: where genetics and pharmacology meet.
@nl
P1433
P1476
Chemical genetics: where genetics and pharmacology meet.
@en
P2093
Kevan M Shokat
P304
P356
10.1016/J.CELL.2007.01.021
P407
P577
2007-02-01T00:00:00Z