Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM.
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Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytesChromatin perturbations during the DNA damage response in higher eukaryotesMouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsisATR: an essential regulator of genome integrityXenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATMATR activation and replication fork restart are defective in FANCM-deficient cells.Combinatorial inhibition of Plk1 and PKCβ in cancer cells with different p53 statusTargeting Ongoing DNA Damage in Multiple Myeloma: Effects of DNA Damage Response Inhibitors on Plasma Cell Survival.Rad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9-Hus1-Rad1 complex at stalled replication forksTranscription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poisonDNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe.TopBP1 and Claspin contribute to the radioresistance of lung cancer brain metastasesTopBP1 functions with 53BP1 in the G1 DNA damage checkpoint.Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress.The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forksDNA structure-specific priming of ATR activation by DNA-PKcsAn essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.RPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling.Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extractsDirect Binding to Replication Protein A (RPA)-coated Single-stranded DNA Allows Recruitment of the ATR Activator TopBP1 to Sites of DNA Damage.An interaction between human papillomavirus 16 E2 and TopBP1 is required for optimum viral DNA replication and episomal genome establishmentSurvival of primary, but not of cancer cells after combined Plk1-HDAC inhibitionDNA mismatch repair and the DNA damage response.TopBP1 activates ATR through ATRIP and a PIKK regulatory domainChemotherapy induced DNA damage response: convergence of drugs and pathwaysDpb11 activates the Mec1-Ddc2 complexDNA double-strand break repair and development.Activation of ATR and related PIKKsThe Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATMBeyond ATM: the protein kinase landscape of the DNA damage response.DNA damage sensing by the ATM and ATR kinases.Importin β-dependent nuclear import of TopBP1 in ATR-Chk1 checkpoint in Xenopus egg extracts.The essential kinase ATR: ensuring faithful duplication of a challenging genome.A role for the MRN complex in ATR activation via TOPBP1 recruitment.HMGA2 inhibits apoptosis through interaction with ATR-CHK1 signaling complex in human cancer cells.Changing of the guard: how ATM hands off DNA double-strand break signaling to ATR.ATR maintains select progenitors during nervous system development.Simplified validation of borderline hits of database searches.Why Human Papillomaviruses Activate the DNA Damage Response (DDR) and How Cellular and Viral Replication Persists in the Presence of DDR Signaling.ATR signaling at a glance.
P2860
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P2860
Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM.
description
2007 nî lūn-bûn
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2007年の論文
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2007年学术文章
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2007年学术文章
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2007年学术文章
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2007年学术文章
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name
Ataxia-telangiectasia mutated ...... sphorylation of TopBP1 by ATM.
@en
type
label
Ataxia-telangiectasia mutated ...... sphorylation of TopBP1 by ATM.
@en
prefLabel
Ataxia-telangiectasia mutated ...... sphorylation of TopBP1 by ATM.
@en
P2093
P2860
P356
P1476
Ataxia-telangiectasia mutated ...... sphorylation of TopBP1 by ATM.
@en
P2093
Akiko Kumagai
Andrej Shevchenko
Anna Shevchenko
Hae Yong Yoo
William G Dunphy
P2860
P304
17501-17506
P356
10.1074/JBC.M701770200
P407
P577
2007-04-19T00:00:00Z