Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells.
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Redox-directed cancer therapeutics: molecular mechanisms and opportunitiesInhibitory effect of acetylshikonin on human gastric carcinoma cell line SGC-7901 in vitro and in vivo.Up-regulation of p21 and TNF-alpha is mediated in lycorine-induced death of HL-60 cells.β,β-Dimethylacrylshikonin sensitizes human colon cancer cells to ionizing radiation through the upregulation of reactive oxygen species.CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemiaIn vitro induction of erythrocyte phosphatidylserine translocation by the natural naphthoquinone shikonin.Transcriptome analysis explores genes related to shikonin biosynthesis in Lithospermeae plants and provides insights into Boraginales' evolutionary history.Shikonin kills glioma cells through necroptosis mediated by RIP-1Topoisomerase I inhibitors, shikonin and topotecan, inhibit growth and induce apoptosis of glioma cells and glioma stem cells.Anti-cancer natural products isolated from chinese medicinal herbsSingle- and Repeat-dose Oral Toxicity Studies of Lithospermum erythrorhizon Extract in Dogs.Induction of apoptosis by 3-amino-6-(3-aminopropyl)-5,6-dihydro-5,11-dioxo-11H-indeno[1,2-c]isoquinoline via modulation of MAPKs (p38 and c-Jun N-terminal kinase) and c-Myc in HL-60 human leukemia cells.New benzimidazole acridine derivative induces human colon cancer cell apoptosis in vitro via the ROS-JNK signaling pathway.Shikonin inhibits IFN-γ-induced K17 over-expression of HaCaT cells by interfering with STAT3 signaling.β-hydroxyisovaleryl-shikonin induces human cervical cancer cell apoptosis via PI3K/AKT/mTOR signalingThe critical role of redox homeostasis in shikonin-induced HL-60 cell differentiation via unique modulation of the Nrf2/ARE pathwayInhibition of c-MYC with involvement of ERK/JNK/MAPK and AKT pathways as a novel mechanism for shikonin and its derivatives in killing leukemia cells.Gallic Acid Induces a Reactive Oxygen Species-Provoked c-Jun NH2-Terminal Kinase-Dependent Apoptosis in Lung FibroblastsShikonin induces apoptosis of HaCaT cells via the mitochondrial, Erk and Akt pathways.Effects of antioxidants and MAPK inhibitors on cell death and reactive oxygen species levels in H2O2-treated human pulmonary fibroblasts.ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells.Shikonin Induces Apoptotic Cell Death via Regulation of p53 and Nrf2 in AGS Human Stomach Carcinoma CellsApoptosis induced by β,β-dimethylacrylshikonin is associated with Bcl-2 and NF-κB in human breast carcinoma MCF-7 cells.Mycobacterium avium MAV2054 protein induces macrophage apoptosis by targeting mitochondria and reduces intracellular bacterial growth.Shikonin potentiates the effect of arsenic trioxide against human hepatocellular carcinoma in vitro and in vivo.Regulation of mammalian target of rapamycin and mitogen activated protein kinase pathways by BCR-ABL.Shikonin and its derivatives: a patent review.NF-κB suppresses ROS levels in BCR-ABL(+) cells to prevent activation of JNK and cell death.Treatment with a JNK inhibitor increases, whereas treatment with a p38 inhibitor decreases, H2O2-induced calf pulmonary arterial endothelial cell death.MAPK inhibitors enhance cell death in pyrogallol-treated human pulmonary fibroblast cells via increasing O2•- levelsMetabolic profiling study of shikonin's cytotoxic activity in the Huh7 human hepatoma cell line.One-pot synthesis of 1,4-dihydroxy-2-((E)-1-hydroxy-4-phenylbut-3-enyl)anthracene-9,10-diones as novel shikonin analogs and evaluation of their antiproliferative activities.Reactive oxygen species and c-Jun N-terminal kinases contribute to TEMPO-induced apoptosis in L5178Y cells.Shikonin, dually functions as a proteasome inhibitor and a necroptosis inducer in multiple myeloma cells.Design, synthesis, and biological evaluation of shikonin and alkannin derivatives as potential anticancer agents via a prodrug approach.Shikonin inhibits the proliferation of human lens epithelial cells by inducing apoptosis through ROS and caspase-dependent pathway.Apoptosis-inducing effects of Melissa officinalis L. essential oil in glioblastoma multiforme cells.Celastrol induces apoptosis in gefitinib-resistant non-small cell lung cancer cells via caspases-dependent pathways and Hsp90 client protein degradation.Olaquindox-induced apoptosis is suppressed through p38 MAPK and ROS-mediated JNK pathways in HepG2 cells.Involvement of MAPK activation and ROS generation in human leukemia U937 cells undergoing apoptosis in response to sonodynamic therapy.
P2860
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P2860
Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Induction of apoptosis by shik ...... logenous leukemia (CML) cells.
@en
Induction of apoptosis by shik ...... e chronic myelogenous leukemia
@nl
type
label
Induction of apoptosis by shik ...... logenous leukemia (CML) cells.
@en
Induction of apoptosis by shik ...... e chronic myelogenous leukemia
@nl
prefLabel
Induction of apoptosis by shik ...... logenous leukemia (CML) cells.
@en
Induction of apoptosis by shik ...... e chronic myelogenous leukemia
@nl
P2093
P2860
P356
P1433
P1476
Induction of apoptosis by shik ...... logenous leukemia (CML) cells.
@en
P2093
Chun Rong Yu
Wen Hua Li
Wen Xin Li
P2860
P2888
P304
P356
10.1038/CR.2008.86
P577
2008-08-01T00:00:00Z