An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway.
about
O-Glycosylated 24 kDa human growth hormone has a mucin-like biantennary disialylated tetrasaccharide attached at Thr-60JAK2 activation by growth hormone and other cytokinesIn vivo targeting of the growth hormone receptor (GHR) Box1 sequence demonstrates that the GHR does not signal exclusively through JAK2.Deletion of IGF-I receptor (IGF-IR) in primary osteoblasts reduces GH-induced STAT5 signaling.Minireview: mechanisms of growth hormone-mediated gene regulation.Molecular interactions of EphA4, growth hormone receptor, Janus kinase 2, and signal transducer and activator of transcription 5B.Human GH receptor-IGF-1 receptor interaction: implications for GH signaling.Dynamic analysis of GH receptor conformational changes by split luciferase complementation.Synergy in ERK activation by cytokine receptors and tyrosine kinase growth factor receptorsIntracellular signaling transduction pathways triggered by a well-known anti-GHR monoclonal antibody, Mab263, in vitro and in vivoA Residue Quartet in the Extracellular Domain of the Prolactin Receptor Selectively Controls Mitogen-activated Protein Kinase SignalingInhibitory GH receptor extracellular domain monoclonal antibodies: three-dimensional epitope mappingGrowth hormone-induced JAK2 signaling and GH receptor down-regulation: role of GH receptor intracellular domain tyrosine residuesGenetic Defects in the Growth Hormone-IGF-I Axis Causing Growth Hormone Insensitivity and Impaired Linear GrowthJAK2, but not Src family kinases, is required for STAT, ERK, and Akt signaling in response to growth hormone in preadipocytes and hepatoma cells.Mitogenic signaling pathways in the liver of growth hormone (GH)-overexpressing mice during the growth periodInterruption of growth hormone signaling via SHC and ERK in 3T3-F442A preadipocytes upon knockdown of insulin receptor substrate-1.Sex differences in the expression of hepatic drug metabolizing enzymes.Research resource: identification of novel growth hormone-regulated phosphorylation sites by quantitative phosphoproteomics.Translating cancer research by synthetic biology.Emerging drugs for acromegaly.A new mechanism for growth hormone receptor activation of JAK2, and implications for related cytokine receptors.Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands.Impact of Growth Hormone on Regulation of Adipose Tissue.A major prolactin-binding complex on human milk fat globule membranes contains cyclophilins A and B: the complex is not the prolactin receptor.βTrCP controls GH receptor degradation via two different motifs.Pivotal Advance: Avian colony-stimulating factor 1 (CSF-1), interleukin-34 (IL-34), and CSF-1 receptor genes and gene products.Lyn activates ERKProtein engineering strategies with potential applications for altering clinically relevant cellular pathways at the protein level.The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects.Allosteric modulation as a unifying mechanism for receptor function and regulation.Cytokine Receptors
P2860
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P2860
An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
An agonist-induced conformatio ...... choice of signalling pathway.
@en
An agonist-induced conformatio ...... choice of signalling pathway.
@nl
type
label
An agonist-induced conformatio ...... choice of signalling pathway.
@en
An agonist-induced conformatio ...... choice of signalling pathway.
@nl
prefLabel
An agonist-induced conformatio ...... choice of signalling pathway.
@en
An agonist-induced conformatio ...... choice of signalling pathway.
@nl
P2093
P2860
P50
P356
P1433
P1476
An agonist-induced conformatio ...... e choice of signalling pathway
@en
P2093
Hideo Yoshizato
John F Hancock
Katherine Nielsen
Kathryn Palethorpe
Kirstin Millard
Linda M Kerr
Michael J Waters
Scott W Rowlinson
Stuart N Behncken
P2860
P2888
P304
P356
10.1038/NCB1737
P577
2008-05-18T00:00:00Z