PAK1 hyperactivation is sufficient for mammary gland tumor formation.
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FRAX597, a Small Molecule Inhibitor of the p21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated SchwannomasSmall molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents.p21-Activated kinase inhibitors: a patent reviewMolecular pathways: targeting p21-activated kinase 1 signaling in cancer--opportunities, challenges, and limitationsLKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domainProtein kinase CK2 phosphorylates and activates p21-activated kinase 1PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesisYeast toxicogenomics: genome-wide responses to chemical stresses with impact in environmental health, pharmacology, and biotechnologyGroup I PAK inhibitor IPA-3 induces cell death and affects cell adhesivity to fibronectin in human hematopoietic cellsInteraction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish developmentPhysical Confirmation and Comparative Genomics of the Rat Mammary carcinoma susceptibility 3 Quantitative Trait LocusOverexpression of PAK1 Correlates with Aberrant Expression of EMT Markers and Poor Prognosis in Non-Small Cell Lung Cancer.Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cellsp21-Activated kinase-1 promotes aggressive phenotype, cell proliferation, and invasion in gestational trophoblastic disease.A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells.PAK1IP1, a ribosomal stress-induced nucleolar protein, regulates cell proliferation via the p53-MDM2 loop.Prognostic importance and therapeutic implications of PAK1, a drugable protein kinase, in gastroesophageal junction adenocarcinoma.PAK1 as a therapeutic target.CD48 on hematopoietic progenitors regulates stem cells and suppresses tumor formation.Pleiotropic functions of Rho GTPase signaling: a Trojan horse or Achilles' heel for breast cancer treatment?Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK.p21-Activated Kinases 1, 2 and 4 in Endometrial Cancers: Effects on Clinical Outcomes and Cell Proliferation.Dysregulation of PAK1 Is Associated with DNA Damage and Is of Prognostic Importance in Primary Esophageal Small Cell Carcinoma.Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo.Rac signaling in breast cancer: a tale of GEFs and GAPs.Potential role of p21 Activated Kinase 1 (PAK1) in the invasion and motility of oral cancer cells.Tyrosyl phosphorylated serine-threonine kinase PAK1 is a novel regulator of prolactin-dependent breast cancer cell motility and invasion.A Derivative of Differentiation-Inducing Factor-3 Inhibits PAK1 Activity and Breast Cancer Cell Proliferation.p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer.Cx26 knockout predisposes the mammary gland to primary mammary tumors in a DMBA-induced mouse model of breast cancerMinireview: Mouse Models of Rho GTPase Function in Mammary Gland Development, Tumorigenesis, and MetastasisThrombin stimulation of inflammatory breast cancer cells leads to aggressiveness via the EGFR-PAR1-Pak1 pathwaySignal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664.Study on the expression of PAK4 and P54 protein in breast cancer.Group I p21-activated kinases regulate thyroid cancer cell migration and are overexpressed and activated in thyroid cancer invasionA tale of two Paks.Pak1, adjuvant tamoxifen therapy, and breast cancer recurrence risk in a Danish population-based study.Prolactin-induced PAK1 tyrosyl phosphorylation promotes FAK dephosphorylation, breast cancer cell motility, invasion and metastasis.Integrated analysis of breast cancer cell lines reveals unique signaling pathways.Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression.
P2860
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P2860
PAK1 hyperactivation is sufficient for mammary gland tumor formation.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
PAK1 hyperactivation is sufficient for mammary gland tumor formation.
@en
PAK1 hyperactivation is sufficient for mammary gland tumor formation.
@nl
type
label
PAK1 hyperactivation is sufficient for mammary gland tumor formation.
@en
PAK1 hyperactivation is sufficient for mammary gland tumor formation.
@nl
prefLabel
PAK1 hyperactivation is sufficient for mammary gland tumor formation.
@en
PAK1 hyperactivation is sufficient for mammary gland tumor formation.
@nl
P2093
P2860
P356
P1433
P1476
PAK1 hyperactivation is sufficient for mammary gland tumor formation.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1209309
P407
P577
2006-05-01T00:00:00Z