Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior.
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TARDBP mutation analysis in TDP-43 proteinopathies and deciphering the toxicity of mutant TDP-43Conjoint pathologic cascades mediated by ALS/FTLD-U linked RNA-binding proteins TDP-43 and FUSNeuroplasticity and Repair in Rodent Neurotoxic Models of Spinal Motoneuron DiseaseTDP-43: a new player on the AD field?The function of RNA-binding proteins at the synapse: implications for neurodegenerationTherapeutic and diagnostic challenges for frontotemporal dementiaDoes a loss of TDP-43 function cause neurodegeneration?TDP-43-mediated neuron loss in vivo requires RNA-binding activityHyperphosphorylation as a defense mechanism to reduce TDP-43 aggregationQuantifying and predicting Drosophila larvae crawling phenotypes.A Case for Microtubule Vulnerability in Amyotrophic Lateral Sclerosis: Altered Dynamics During DiseaseDrosophila as an In Vivo Model for Human Neurodegenerative DiseaseIdentification of genetic modifiers of TDP-43 neurotoxicity in DrosophilaA modular toolset for recombination transgenesis and neurogenetic analysis of DrosophilaKnockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degenerationLoss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis.Expansive gene transfer in the rat CNS rapidly produces amyotrophic lateral sclerosis relevant sequelae when TDP-43 is overexpressed.The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth.Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.Role of BMP receptor traffic in synaptic growth defects in an ALS model.Transgenic rat model of neurodegeneration caused by mutation in the TDP gene.Motor neuron expression of the voltage-gated calcium channel cacophony restores locomotion defects in a Drosophila, TDP-43 loss of function model of ALS.TDP-43 is a developmentally regulated protein essential for early embryonic development.Development of a novel nonradiometric assay for nucleic acid binding to TDP-43 suitable for high-throughput screening using AlphaScreen technology.A Drosophila model for TDP-43 proteinopathy.Modelling amyotrophic lateral sclerosis: progress and possibilitiesTDP-43 regulates its mRNA levels through a negative feedback loop.Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS).TDP-43 regulates Drosophila neuromuscular junctions growth by modulating Futsch/MAP1B levels and synaptic microtubules organizationDrosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects.Neuronal function and dysfunction of Drosophila dTDPDrosophila melanogaster in the study of human neurodegeneration.Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43.Neurodegenerative models in Drosophila: polyglutamine disorders, Parkinson disease, and amyotrophic lateral sclerosis.Nuclear TAR DNA-binding protein 43: A new target for amyotrophic lateral sclerosis treatmentKank Is an EB1 interacting protein that localises to muscle-tendon attachment sites in Drosophila.The aggregation and neurotoxicity of TDP-43 and its ALS-associated 25 kDa fragment are differentially affected by molecular chaperones in Drosophila.Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.Knockdown of the Drosophila fused in sarcoma (FUS) homologue causes deficient locomotive behavior and shortening of motoneuron terminal branches.
P2860
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P2860
Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Depletion of TDP-43 affects Dr ...... apsis and locomotive behavior.
@en
Depletion of TDP-43 affects Dr ...... apsis and locomotive behavior.
@nl
type
label
Depletion of TDP-43 affects Dr ...... apsis and locomotive behavior.
@en
Depletion of TDP-43 affects Dr ...... apsis and locomotive behavior.
@nl
prefLabel
Depletion of TDP-43 affects Dr ...... apsis and locomotive behavior.
@en
Depletion of TDP-43 affects Dr ...... apsis and locomotive behavior.
@nl
P2093
P2860
P1433
P1476
Depletion of TDP-43 affects Dr ...... apsis and locomotive behavior.
@en
P2093
Andrea D'Ambrogio
Fabian Feiguin
Francisco E Baralle
Giulia Romano
Raffaella Klima
Vinay K Godena
P2860
P304
P356
10.1016/J.FEBSLET.2009.04.019
P407
P577
2009-04-19T00:00:00Z