about
Gene targeting, genome editing: from Dolly to editorsResources for the design of CRISPR gene editing experimentsMinimizing off-Target Mutagenesis Risks Caused by Programmable NucleasesCRISPR-Cas9: A Revolutionary Tool for Cancer ModellingOff-target Effects in CRISPR/Cas9-mediated Genome EngineeringBiased and Unbiased Methods for the Detection of Off-Target Cleavage by CRISPR/Cas9: An OverviewUnexpected mutations after CRISPR–Cas9 editing in vivoA Convenient Cas9-based Conditional Knockout Strategy for Simultaneously Targeting Multiple Genes in Mouse.CRISPR/Cas9 Immune System as a Tool for Genome Engineering.The moral imperative to continue gene editing research on human embryos.Breaking-Cas-interactive design of guide RNAs for CRISPR-Cas experiments for ENSEMBL genomes.Genome Editing with CRISPR-Cas9: Can It Get Any Better?Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR.Deep Brain Photoreceptor (val-opsin) Gene Knockout Using CRISPR/Cas Affects Chorion Formation and Embryonic Hatching in the Zebrafish.One-step generation of triple gene-targeted pigs using CRISPR/Cas9 systemEfficient generation of FVII gene knockout mice using CRISPR/Cas9 nuclease and truncated guided RNAs.Increasing the efficiency of CRISPR/Cas9-mediated precise genome editing in rats by inhibiting NHEJ and using Cas9 protein.Efficient liver repopulation of transplanted hepatocyte prevents cirrhosis in a rat model of hereditary tyrosinemia type IReal-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9.Efficient Generation of Orthologous Point Mutations in Pigs via CRISPR-assisted ssODN-mediated Homology-directed Repair.Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryosOptimization of the production of knock-in alleles by CRISPR/Cas9 microinjection into the mouse zygote.Sharing mutations: are biobanks still required in the post-CRISPR/Cas9 era?Modeling Disease In Vivo With CRISPR/Cas9.Creating and evaluating accurate CRISPR-Cas9 scalpels for genomic surgery.Salient Features of Endonuclease Platforms for Therapeutic Genome EditingCRISPR-Cas orthologues and variants: optimizing the repertoire, specificity and delivery of genome engineering tools.In vivo blunt-end cloning through CRISPR/Cas9-facilitated non-homologous end-joiningDefining and improving the genome-wide specificities of CRISPR-Cas9 nucleases.Genome editing in nonhuman primates: approach to generating human disease models.Polygenic Causes of Congenital Diaphragmatic Hernia Produce Common Lung Pathologies.Post-modern therapeutic approaches for progressive myoclonus epilepsy.Gene Drive for Mosquito Control: Where Did It Come from and Where Are We Headed?Simplified CRISPR tools for efficient genome editing and streamlined protocols for their delivery into mammalian cells and mouse zygotes.Efficient Generation of Gene-Modified Pigs Harboring Precise Orthologous Human Mutation via CRISPR/Cas9-Induced Homology-Directed Repair in Zygotes.One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs.Exome sequencing in the knockin mice generated using the CRISPR/Cas system.CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington's disease.The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy.CRISPR/Cas9-mediated targeted chromosome elimination.
P2860
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P2860
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
Off-target mutations are rare in Cas9-modified mice.
@en
Off-target mutations are rare in Cas9-modified mice.
@nl
type
label
Off-target mutations are rare in Cas9-modified mice.
@en
Off-target mutations are rare in Cas9-modified mice.
@nl
prefLabel
Off-target mutations are rare in Cas9-modified mice.
@en
Off-target mutations are rare in Cas9-modified mice.
@nl
P2093
P2860
P356
P1433
P1476
Off-target mutations are rare in Cas9-modified mice
@en
P2093
Thomas Keane
Vivek Iyer
Wensheng Zhang
William C Skarnes
Xingxu Huang
P2860
P2888
P356
10.1038/NMETH.3408
P577
2015-06-01T00:00:00Z