Cdk5 is a key factor in tau aggregation and tangle formation in vivo.
about
Recent developments of protein kinase inhibitors as potential AD therapeuticsExcitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brainsInhibition of calpain prevents NMDA-induced cell death and beta-amyloid-induced synaptic dysfunction in hippocampal slice culturesSilencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's miceCurcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st centuryPhysiological and pathological phosphorylation of tau by Cdk5Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targetsInnate immunity in Alzheimer's disease: a complex affairCHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survivalDown-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's diseaseActivation of latent cyclin-dependent kinase 5 (Cdk5)-p35 complexes by membrane dissociationPhosphorylation of FTDP-17 mutant tau by cyclin-dependent kinase 5 complexed with p35, p25, or p39A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neuronsZebrafish models of TauopathyTau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments.GSK-3: Functional Insights from Cell Biology and Animal Models.The involvement of Cdk5 activator p35 in social isolation-triggered onset of early Alzheimer's disease-related cognitive deficit in the transgenic mice.Alterations in synaptic plasticity coincide with deficits in spatial working memory in presymptomatic 3xTg-AD mice.Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease.No association of CDK5 genetic variants with Alzheimer's disease risk.Roles of tau protein in health and disease.Tau phosphorylation induced by severe closed head traumatic brain injury is linked to the cellular prion proteinSuppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis.Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function.Association of GSK3B with Alzheimer disease and frontotemporal dementiaInhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivoA DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration.ASIP Outstanding Investigator Award Lecture. New approaches to the pathology and genetics of neurodegenerationTransgenic models of Alzheimer's disease: learning from animalsMechanisms of tau-induced neurodegeneration.Synaptic roles of cyclin-dependent kinase 5 & its implications in epilepsyNovel screening cascade identifies MKK4 as key kinase regulating Tau phosphorylation at Ser422.Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments.Alpha7 nicotinic acetylcholine receptor: a link between inflammation and neurodegeneration.Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease.Implicating calpain in tau-mediated toxicity in vivo.Potential therapeutic strategies for Alzheimer's disease targeting or beyond β-amyloid: insights from clinical trialsProteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's miceLoss of Hsp110 leads to age-dependent tau hyperphosphorylation and early accumulation of insoluble amyloid beta.
P2860
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P2860
Cdk5 is a key factor in tau aggregation and tangle formation in vivo.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Cdk5 is a key factor in tau aggregation and tangle formation in vivo.
@en
Cdk5 is a key factor in tau aggregation and tangle formation in vivo.
@nl
type
label
Cdk5 is a key factor in tau aggregation and tangle formation in vivo.
@en
Cdk5 is a key factor in tau aggregation and tangle formation in vivo.
@nl
prefLabel
Cdk5 is a key factor in tau aggregation and tangle formation in vivo.
@en
Cdk5 is a key factor in tau aggregation and tangle formation in vivo.
@nl
P2093
P50
P1433
P1476
Cdk5 is a key factor in tau aggregation and tangle formation in vivo.
@en
P2093
Evelyn Casey
John LaFrancois
Jordana Meyerson
Karen Duff
Kate Gaynor
Kazuyuki Takata
Lit-Fui Lau
Michael Ahlijanian
P304
P356
10.1016/S0896-6273(03)00259-9
P407
P577
2003-05-01T00:00:00Z