Alternative splicing of human insulin receptor messenger RNA.
about
hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor geneInteraction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicingaxl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinaseDiabetes reduces autophosphorylation of retinal insulin receptor and increases protein-tyrosine phosphatase-1B activityGenome-wide review of transcriptional complexity in mouse protein kinases and phosphatases.How insulin engages its primary binding site on the insulin receptorAlternatively spliced variants of the insulin receptor protein. Expression in normal and diabetic human tissuesInsulin in the brain: its pathophysiological implications for States related with central insulin resistance, type 2 diabetes and Alzheimer's diseaseMBNL1 is the primary determinant of focus formation and aberrant insulin receptor splicing in DM1Engineering of insulin receptor isoform-selective insulin analoguesSequencing analysis of insulin receptor defects and detection of two novel mutations in INSR geneRILM: a web-based resource to aid comparative and functional analysis of the insulin and IGF-1 receptor family.First molecular diagnosis of Donohue syndrome in Africa: novel unusual insertion/deletion mutation in the INSR gene.Tailoring of membrane proteins by alternative splicing of pre-mRNA.Alternative splicing generates isoforms of the met receptor tyrosine kinase which undergo differential processingAntisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB.A comparative structural bioinformatics analysis of the insulin receptor family ectodomain based on phylogenetic information.Role of receptor tyrosine kinases and their ligands in glioblastoma.Insulin receptor splicing alteration in myotonic dystrophy type 2.Role of PC-1 in the etiology of insulin resistance.Muscleblind-like 1 (Mbnl1) promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic enhancer.Hyperinsulinemia is associated with altered insulin receptor mRNA splicing in muscle of the spontaneously obese diabetic rhesus monkey.Insight into the molecular basis for the kinetic differences between the two insulin receptor isoforms.Five mutant alleles of the insulin receptor gene in patients with genetic forms of insulin resistance.Molecular mechanism of insulin resistance in type 2 diabetes mellitus: role of the insulin receptor variant forms.Membrane-associated and soluble granulocyte/macrophage-colony-stimulating factor receptor alpha subunits are independently regulated in HL-60 cellsA truncated, secreted form of the epidermal growth factor receptor is encoded by an alternatively spliced transcript in normal rat tissue.Reconstitution of insulin action in muscle, white adipose tissue, and brain of insulin receptor knock-out mice fails to rescue diabetes.Alternative splicing of human insulin receptor gene (INSR) in type I and type II skeletal muscle fibers of patients with myotonic dystrophy type 1 and type 2.Structural basis for the lower affinity of the insulin-like growth factors for the insulin receptor.Functionally distinct insulin receptors generated by tissue-specific alternative splicing.The paired basic amino acid-cleaving enzyme 4 (PACE4) is involved in the maturation of insulin receptor isoform B: an opportunity to reduce the specific insulin receptor-dependent effects of insulin-like growth factor 2 (IGF2).Regulation of human insulin receptor RNA splicing in vivo.Improved glucose metabolism in vitro and in vivo by an allosteric monoclonal antibody that increases insulin receptor binding affinityAberrant liver insulin receptor isoform a expression normalises with remission of type 2 diabetes after gastric bypass surgery.Ligand-Binding Affinity at the Insulin Receptor Isoform-A and Subsequent IR-A Tyrosine Phosphorylation Kinetics are Important Determinants of Mitogenic Biological Outcomes.Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.Insulin and insulin-like growth factor II differentially regulate endocytic sorting and stability of insulin receptor isoform AInsulin receptor isotype expression correlates with risk of non-insulin-dependent diabetes.Isoform-specific insulin receptor signaling involves different plasma membrane domains.
P2860
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P2860
Alternative splicing of human insulin receptor messenger RNA.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年学术文章
@wuu
1989年学术文章
@zh-cn
1989年学术文章
@zh-hans
1989年学术文章
@zh-my
1989年学术文章
@zh-sg
1989年學術文章
@yue
1989年學術文章
@zh
1989年學術文章
@zh-hant
name
Alternative splicing of human insulin receptor messenger RNA.
@en
Alternative splicing of human insulin receptor messenger RNA.
@nl
type
label
Alternative splicing of human insulin receptor messenger RNA.
@en
Alternative splicing of human insulin receptor messenger RNA.
@nl
prefLabel
Alternative splicing of human insulin receptor messenger RNA.
@en
Alternative splicing of human insulin receptor messenger RNA.
@nl
P1476
Alternative splicing of human insulin receptor messenger RNA.
@en
P304
P356
10.1016/0006-291X(89)92439-X
P407
P577
1989-02-01T00:00:00Z