Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease.
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Model systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicityBridging the gap between statistical and biological epistasis in Alzheimer's diseaseChronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease.Lipid and Alzheimer's disease genes associated with healthy aging and longevity in healthy oldest-old.Characterizing the altered cellular proteome induced by the stress-independent activation of heat shock factor 1.Syntheses, neural protective activities, and inhibition of glycogen synthase kinase-3β of substituted quinolines.Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice.Heat shock response and autophagy--cooperation and control.Heat shock factor 1 over-expression protects against exposure of hydrophobic residues on mutant SOD1 and early mortality in a mouse model of amyotrophic lateral sclerosis.Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPKHeat shock alters the expression of schizophrenia and autism candidate genes in an induced pluripotent stem cell model of the human telencephalonHippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathologyGenome-wide association interaction analysis for Alzheimer's disease.VGF expression by T lymphocytes in patients with Alzheimer's diseaseDeterminants of rodent longevity in the chaperone-protein degradation network.Rapamycin, Autophagy, and Alzheimer's DiseaseTargeting the mTOR signaling network for Alzheimer's disease therapy.Natural compounds with anti-ageing activity.Barcoding heat shock proteins to human diseases: looking beyond the heat shock responseMolecular chaperones and neuronal proteostasis.Activation of mTOR: a culprit of Alzheimer's disease?mTOR in Brain Physiology and Pathologies.Walking the tightrope: proteostasis and neurodegenerative disease.Does any drug to treat cancer target mTOR and iron hemostasis in neurodegenerative disorders?Cellular Regulation of Amyloid Formation in Aging and Disease.Assessment of Autophagy in Neurons and Brain Tissue.Loss of malin, but not laforin, results in compromised autophagic flux and proteasomal dysfunction in cells exposed to heat shock.Heat shock in the springtime.A Perfect sTORm: The Role of the Mammalian Target of Rapamycin (mTOR) in Cerebrovascular Dysfunction of Alzheimer's Disease: A Mini-Review.Regulation of heat shock transcription factors and their roles in physiology and disease.Overexpression of heat shock factor 1 maintains TAR DNA binding protein 43 solubility via induction of inducible heat shock protein 70 in cultured cells.mTOR: at the crossroads of aging, chaperones, and Alzheimer's disease.
P2860
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P2860
Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Over-expression of heat shock ...... in mice modeling the disease.
@en
Over-expression of heat shock ...... in mice modeling the disease.
@nl
type
label
Over-expression of heat shock ...... in mice modeling the disease.
@en
Over-expression of heat shock ...... in mice modeling the disease.
@nl
prefLabel
Over-expression of heat shock ...... in mice modeling the disease.
@en
Over-expression of heat shock ...... in mice modeling the disease.
@nl
P2093
P2860
P356
P1476
Over-expression of heat shock ...... s in mice modeling the disease
@en
P2093
Anson Pierce
Jonathan J Halloran
Matthew J Hart
Natalia Podlutskaya
Pei-Yi Lin
Raquel Burbank
Stacy A Hussong
Veronica Galvan
P2860
P304
P356
10.1111/JNC.12080
P407
P577
2012-12-26T00:00:00Z