The T cell repertoire may be biased in favor of MHC recognition.
about
Diversity of γδ T-cell antigensStructural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'Crossreactive T Cells Spotlight the Germline Rules for αβ T Cell-Receptor Interactions with MHC MoleculesEffect of CDR3 Sequences and Distal V Gene Residues in Regulating TCR-MHC Contacts and Ligand SpecificityGermline-encoded amino acids in the alphabeta T-cell receptor control thymic selectionMHC restriction is imposed on a diverse T cell receptor repertoire by CD4 and CD8 co-receptors during thymic selectionT cells and their eons-old obsession with MHCThe molecular basis of TCR germline bias for MHC is surprisingly simpleDirected evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines.Anti-L3T4 antibody inhibits the lysis of H-2 class II antigen-negative target cells by L3T4+ cytotoxic T lymphocytesThe T-cell accessory molecule CD4 recognizes a monomorphic determinant on isolated Ia.Coevolution of TCR-MHC interactions: conserved MHC tertiary structure is not sufficient for interactions with the TCR.Delineation of antigen contact residues on an MHC class II molecule.Thymic selection stifles TCR reactivity with the main chain structure of MHC and forces interactions with the peptide side chains.Two mechanisms that account for major histocompatibility complex restriction of T cells.Antigen/major histocompatibility complex-specific activation of murine T cells transfected with functionally rearranged T-cell receptor genes.Generation of MHC class II-peptide ligands for CD4 T-cell allorecognition of MHC class II molecules.Regulatory T cells for tolerance therapy: revisiting the concept.Evolutionarily conserved features contribute to αβ T cell receptor specificityNegative selection imparts peptide specificity to the mature T cell repertoire.The Lyt-2 molecule recognizes residues in the class I alpha 3 domain in allogeneic cytotoxic T cell responses.The MHC molecule I-E is necessary but not sufficient for the clonal deletion of V beta 11-bearing T cellsI-A alpha polymorphic residues that determine alloreactive T cell recognition.Identical peptides recognized by MHC class I- and II-restricted T cells.How many thymocytes audition for selection?Functional evidence for TCR-intrinsic specificity for MHCII.The influence of maternal prenatal and early childhood nutrition and maternal prenatal stress on offspring immune system development and neurodevelopmental disorders.Evolutionarily conserved amino acids that control TCR-MHC interaction.Many different Vbeta CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions.The generation and selection of the T cell repertoire: insights from studies of the molecular basis of T cell recognition.The molecular basis of MHC-restricted antigen recognition by T cells.Human TCR-MHC coevolution after divergence from mice includes increased nontemplate-encoded CDR3 diversity.Intracellular recognition events eliminate self-reactive T cells.Cell-mediated immunity in virus infections of the central nervous system.T-cell specificity and repertoire.Recognition of the major histocompatibility complex restriction element modulates CD8(+) T cell specificity and compensates for loss of T cell receptor contacts with the specific peptideAlloreactivity, antigen recognition and T-cell selection: three diverse T-cell recognition problems with a common solution.Crossreactive αβ T Cell Receptors Are the Predominant Targets of Thymocyte Negative Selection.
P2860
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P2860
The T cell repertoire may be biased in favor of MHC recognition.
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年学术文章
@wuu
1986年学术文章
@zh
1986年学术文章
@zh-cn
1986年学术文章
@zh-hans
1986年学术文章
@zh-my
1986年学术文章
@zh-sg
1986年學術文章
@yue
1986年學術文章
@zh-hant
name
The T cell repertoire may be biased in favor of MHC recognition.
@en
The T cell repertoire may be biased in favor of MHC recognition.
@nl
type
label
The T cell repertoire may be biased in favor of MHC recognition.
@en
The T cell repertoire may be biased in favor of MHC recognition.
@nl
prefLabel
The T cell repertoire may be biased in favor of MHC recognition.
@en
The T cell repertoire may be biased in favor of MHC recognition.
@nl
P2093
P1433
P1476
The T cell repertoire may be biased in favor of MHC recognition
@en
P2093
C Coleclough
M Blackman
P304
P356
10.1016/0092-8674(86)90591-X
P407
P577
1986-11-01T00:00:00Z