Transforming growth factor-beta 1 potentiates amyloid-beta generation in astrocytes and in transgenic mice. - Wikidata - wikimedia - TriplyDB

Transforming growth factor-beta 1 potentiates amyloid-beta generation in astrocytes and in transgenic mice.

Transforming growth factor-beta 1 potentiates amyloid-beta generation in astrocytes and in transgenic mice.

http://www.wikidata.org/entity/Q48369527

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Astrocytes as a source for extracellular matrix molecules and cytokines Close association of water channel AQP1 with amyloid-beta deposition in Alzheimer disease brains Transforming growth factor beta2 is a neuronal death-inducing ligand for amyloid-beta precursor protein Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised Modelling neuroinflammatory phenotypes in vivo PuF, an antimetastatic and developmental signaling protein, interacts with the Alzheimer's amyloid-β precursor protein via a tissue-specific proximal regulatory element (PRE)Comprehensive transcriptional profiling of prion infection in mouse models reveals networks of responsive genes Brain injury-associated biomarkers of TGF-beta1, S100B, GFAP, NF-L, tTG, AbetaPP, and tau were concomitantly enhanced and the UPS was impaired during acute brain injury caused by Toxocara canis in mice.Transforming growth factor-(beta)s and mammary gland involution; functional roles and implications for cancer progression.Transgenic models of Alzheimer's disease: learning from animals Icariin ameliorates neuropathological changes, TGF-β1 accumulation and behavioral deficits in a mouse model of cerebral amyloidosis MicroRNA-153 physiologically inhibits expression of amyloid-β precursor protein in cultured human fetal brain cells and is dysregulated in a subset of Alzheimer disease patients.Transgenic mice overexpressing APP and transforming growth factor-beta1 feature cognitive and vascular hallmarks of Alzheimer's disease TGF-β1 protection against Aβ1-42-induced neuroinflammation and neurodegeneration in rats.Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease Association of a polymorphism of the transforming growth factor-beta1 gene with cerebral amyloid angiopathy.Smad3-dependent signaling underlies the TGF-β1-mediated enhancement in astrocytic iNOS expression Interleukin17A Promotes Postoperative Cognitive Dysfunction by Triggering β-Amyloid Accumulation via the Transforming Growth Factor-β (TGFβ)/Smad Signaling Pathway Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme.Signaling pathways regulating neuron-glia interaction and their implications in Alzheimer's disease.Neuroinflammation in autism spectrum disorders The TGF-beta1/upstream stimulatory factor-regulated PAI-1 gene: potential involvement and a therapeutic target in Alzheimer's disease Vitamin D interacts with Esr1 and Igf1 to regulate molecular pathways relevant to Alzheimer's disease Role of the Transforming-Growth-Factor-β1 Gene in Late-Onset Alzheimer's Disease: Implications for the Treatment TGF beta2-induced changes in LRP-1/T beta R-V and the impact on lysosomal A beta uptake and neurotoxicity.Assessment of allele-specific gene silencing by RNA interference with mutant and wild-type reporter alleles.Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases.Translational regulation of BACE-1 expression in neuronal and non-neuronal cells.Reactive astrocytes as therapeutic targets for CNS disorders.Vascular damage in the central nervous system: a multifaceted role for vascular-derived TGF-β.Age-dependent changes on TGFβ1 Smad3 pathway modify the pattern of microglial cell activation.RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo.The amyloid-beta peptide suppresses transforming growth factor-beta1-induced matrix metalloproteinase-2 production via Smad7 expression in human monocytic THP-1 cells.Sp1 and Smad transcription factors co-operate to mediate TGF-beta-dependent activation of amyloid-beta precursor protein gene transcription.Novel Combinatorial Therapeutic Targeting of PAI-1 (SERPINE1) Gene Expression in Alzheimer's Disease Role of TGFβ signaling in the pathogenesis of Alzheimer's disease.Aβ internalization by neurons and glia.The role of astrocytes in amyloid production and Alzheimer's disease.Involvement of Astrocytes in Alzheimer's Disease from a Neuroinflammatory and Oxidative Stress Perspective.Glial Draper Rescues Aβ Toxicity in a Drosophila Model of Alzheimer's Disease.

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Transforming growth factor-beta 1 potentiates amyloid-beta generation in astrocytes and in transgenic mice.

http://www.wikidata.org/entity/Q48369527

description

2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

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2003年學術文章

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name

Transforming growth factor-bet ...... ocytes and in transgenic mice.

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Transforming growth factor-bet ...... ocytes and in transgenic mice.

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type

label

Transforming growth factor-bet ...... ocytes and in transgenic mice.

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Transforming growth factor-bet ...... ocytes and in transgenic mice.

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prefLabel

Transforming growth factor-bet ...... ocytes and in transgenic mice.

@en

Transforming growth factor-bet ...... ocytes and in transgenic mice.

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Transforming growth factor-bet ...... ocytes and in transgenic mice.

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André Delacourte

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Cecilia Gabriel

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Debomoy K Lahiri

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Laurent Plawinski

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P2860

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

Characterization of functional domains within Smad4/DPC4

Mechanism of activation of the TGF-beta receptor

Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene.

How cells read TGF-beta signals

Beta-amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology.

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

Molecular cloning of the promoter of the gene encoding the Rhesus monkey beta-amyloid precursor protein: structural characterization and a comparative study with other species.

Chimeric extracellular domain type II transforming growth factor (TGF)-beta receptor fused to the Fc region of human immunoglobulin as a TGF-beta antagonist.

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278

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Eric T MacKenzie

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Géraldine Liot

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2003-03-07T00:00:00Z

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12626500

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