Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice.
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Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's diseaseNeurotrophic factors in Alzheimer’s disease: role of axonal transportAlzheimer's disease as homeostatic responses to age-related myelin breakdownPathways towards and away from Alzheimer's diseaseGalanin in Alzheimer's disease: neuroinhibitory or neuroprotective?Presenilins are essential for regulating neurotransmitter releaseThe amyloid precursor protein: beyond amyloidAmyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's diseaseAxonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cellsEntorhinal cortical defects in Tg2576 mice are present as early as 2-4 months of age.Diminished CRE-Induced Plasticity is Linked to Memory Deficits in Familial Alzheimer's Disease MiceTrafficking and proteolytic processing of APPAnti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's diseaseDistinct pools of non-glycolytic substrates differentiate brain regions and prime region-specific responses of mitochondriaAxonal transport and neurodegenerative disease: can we see the elephant?Amyloid Beta annular protofibrils in cell processes and synapses accumulate with aging and Alzheimer-associated genetic modificationDifferential release of β-amyloid from dendrite- versus axon-targeted APP.BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites.Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network.Alzheimer disease models and human neuropathology: similarities and differencesAmyloid beta from axons and dendrites reduces local spine number and plasticity.Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: digital morphometric analysesAxonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPaseEffects of diet on brain plasticity in animal and human studies: mind the gap.Alzheimer precursor protein interaction with the Nogo-66 receptor reduces amyloid-beta plaque depositionBeta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque developmentKinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolismTraumatic brain injury reduces soluble extracellular amyloid-β in mice: a methodologically novel combined microdialysis-controlled cortical impact study.Aberrant subcellular neuronal calcium regulation in aging and Alzheimer's diseaseAmyloid-β as a modulator of synaptic plasticityObservations in APP bitransgenic mice suggest that diffuse and compact plaques form via independent processes in Alzheimer's disease.Brainstem Alzheimer's-like pathology in the triple transgenic mouse model of Alzheimer's disease.Amyloid deposition in the hippocampus and entorhinal cortex: quantitative analysis of a transgenic mouse model.Evidence for Alzheimer's disease-linked synapse loss and compensation in mouse and human hippocampal CA1 pyramidal neurons.Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanismsPresynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis.Neuronal activity regulates the regional vulnerability to amyloid-β deposition.Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro.DHA diet reduces AD pathology in young APPswe/PS1 Delta E9 transgenic mice: possible gender effects
P2860
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P2860
Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Evidence that synaptically rel ...... ippocampus of transgenic mice.
@en
Evidence that synaptically rel ...... ippocampus of transgenic mice.
@nl
type
label
Evidence that synaptically rel ...... ippocampus of transgenic mice.
@en
Evidence that synaptically rel ...... ippocampus of transgenic mice.
@nl
prefLabel
Evidence that synaptically rel ...... ippocampus of transgenic mice.
@en
Evidence that synaptically rel ...... ippocampus of transgenic mice.
@nl
P2093
P1476
Evidence that synaptically rel ...... hippocampus of transgenic mice
@en
P2093
Daniel A Peterson
Michael Lee
Orly Lazarov
Sangram S Sisodia
P304
P356
10.1523/JNEUROSCI.22-22-09785.2002
P407
P577
2002-11-01T00:00:00Z