Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy.
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Is tau ready for admission to the prion club?Tangles, Toxicity, and Tau Secretion in AD - New Approaches to a Vexing ProblemOverexpression of Mineralocorticoid Receptors Partially Prevents Chronic Stress-Induced Reductions in Hippocampal Memory and Structural PlasticityGenotype-specific differences between mouse CNS stem cell lines expressing frontotemporal dementia mutant or wild type human tauIncreasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L miceTau-mediated synaptic damage in Alzheimer's diseaseDifferent pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer's disease and frontotemporal lobar degenerationIncreased dendritic spine density and tau expression are associated with individual differences in steroidal regulation of male sexual behavior.Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments.Changes in dendritic complexity and spine morphology in transgenic mice expressing human wild-type tau.Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice.Aggregation of detergent-insoluble tau is involved in neuronal loss but not in synaptic lossElectrophysiological changes precede morphological changes to frontal cortical pyramidal neurons in the rTg4510 mouse model of progressive tauopathyThe role of hippocampal tau protein phosphorylation in isoflurane-induced cognitive dysfunction in transgenic APP695 mice.Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylationRetinoic acid restores adult hippocampal neurogenesis and reverses spatial memory deficit in vitamin A deprived rats.Two-dimensional electrophoresis of tau mutants reveals specific phosphorylation pattern likely linked to early tau conformational changes.Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs.Probing the biology of Alzheimer's disease in mice.Protein tau: prime cause of synaptic and neuronal degeneration in Alzheimer's disease.Individual variations in maternal care early in life correlate with later life decision-making and c-fos expression in prefrontal subregions of ratsDopaminergic modulation of cortical plasticity in Alzheimer's disease patients.Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficitsApparent behavioral benefits of tau overexpression in P301L tau transgenic miceLead dysregulates serine/threonine protein phosphatases in human neurons.Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration.Early maternal deprivation affects dentate gyrus structure and emotional learning in adult female rats.Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathyP301L tau expression affects glutamate release and clearance in the hippocampal trisynaptic pathway.Induction of intracellular tau aggregation is promoted by α-synuclein seeds and provides novel insights into the hyperphosphorylation of tau.Prolonged running, not fluoxetine treatment, increases neurogenesis, but does not alter neuropathology, in the 3xTg mouse model of Alzheimer's diseasePostsynaptic degeneration as revealed by PSD-95 reduction occurs after advanced Aβ and tau pathology in transgenic mouse models of Alzheimer's diseaseAberrant dendritic excitability: a common pathophysiology in CNS disorders affecting memory?Neurogenesis and cell cycle-reactivated neuronal death during pathogenic tau aggregationMalignant synaptic growth and Alzheimer's disease.Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylationKnock-out and transgenic mouse models of tauopathies.Synaptic alterations in the rTg4510 mouse model of tauopathy.Reduced early hypoxic/ischemic brain damage is associated with increased GLT-1 levels in mice expressing mutant (P301L) human tau.Early structural and functional defects in synapses and myelinated axons in stratum lacunosum moleculare in two preclinical models for tauopathy.
P2860
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P2860
Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Improved long-term potentiatio ...... phosphorylation and tauopathy.
@en
Improved long-term potentiatio ...... phosphorylation and tauopathy.
@nl
type
label
Improved long-term potentiatio ...... phosphorylation and tauopathy.
@en
Improved long-term potentiatio ...... phosphorylation and tauopathy.
@nl
prefLabel
Improved long-term potentiatio ...... phosphorylation and tauopathy.
@en
Improved long-term potentiatio ...... phosphorylation and tauopathy.
@nl
P2093
P1476
Improved long-term potentiatio ...... rphosphorylation and tauopathy
@en
P2093
Barbara Biemans
Dick Terwel
Fred van Leuven
Ger J A Ramakers
Harm Krugers
Hiroshi Mori
Karin Boekhoorn
Koos de Vos
Olof Wiegert
Paul J Lucassen
P304
P356
10.1523/JNEUROSCI.5425-05.2006
P407
P50
P577
2006-03-01T00:00:00Z