Phosphatidylinositol 4,5-bisphosphate and intracellular pH regulate the ROMK1 potassium channel via separate but interrelated mechanisms.
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A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: implication for Andersen's syndrome.How highly charged anionic lipids bind and regulate ion channelsPhosphoinositide regulation of inward rectifier potassium (Kir) channelsKCNJ10 gene mutations causing EAST syndrome (epilepsy, ataxia, sensorineural deafness, and tubulopathy) disrupt channel functionDepletion of phosphatidylinositol 4,5-bisphosphate by activation of phospholipase C-coupled receptors causes slow inhibition but not desensitization of G protein-gated inward rectifier K+ current in atrial myocytes.Molecular diversity and regulation of renal potassium channels.Hypertension resistance polymorphisms in ROMK (Kir1.1) alter channel function by different mechanisms.Subunit-subunit interactions are critical for proton sensitivity of ROMK: evidence in support of an intermolecular gating mechanismRole of conserved glycines in pH gating of Kir1.1 (ROMK)Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase.Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels.Phosphoinositide control of membrane protein function: a frontier led by studies on ion channels.Sensitivity of TRPM7 channels to Mg2+ characterized in cell-free patches of Jurkat T lymphocytesHydrolyzable ATP and PIP(2) modulate the small-conductance K+ channel in apical membranes of rat cortical-collecting duct (CCD).Biophysical and molecular mechanisms underlying the modulation of heteromeric Kir4.1-Kir5.1 channels by CO2 and pH.PIP2 activates TRPV5 and releases its inhibition by intracellular Mg2+.Gabapentin activates ROMK1 channels by a protein kinase A (PKA)-dependent mechanism.Diverse Kir modulators act in close proximity to residues implicated in phosphoinositide binding.Energetics and location of phosphoinositide binding in human Kir2.1 channels.Long-pore electrostatics in inward-rectifier potassium channels.Inhibition of ROMK channels by low extracellular K+ and oxidative stress.A comprehensive guide to the ROMK potassium channel: form and function in health and disease.Channelopathies linked to plasma membrane phosphoinositides.The salt-wasting phenotype of EAST syndrome, a disease with multifaceted symptoms linked to the KCNJ10 K+ channel.Random mutagenesis screening indicates the absence of a separate H(+)-sensor in the pH-sensitive Kir channels.Evidence for endocytosis of ROMK potassium channel via clathrin-coated vesicles.Mechanism and molecular determinant for regulation of rabbit transient receptor potential type 5 (TRPV5) channel by extracellular pH.Structural determinants and specificities for ROMK1-phosphoinositide interaction.Structural rearrangements underlying ligand-gating in Kir channels.Intrinsic sensitivity of Kir1.1 (ROMK) to glibenclamide in the absence of SUR2B. Implications for the identity of the renal ATP-regulated secretory K+ channel.Inhibition of G-protein-coupled inward rectifying K+ channels by intracellular acidosis.Phosphatidylinositol 4,5-bisphosphate (PIP2) modulation of ATP and pH sensitivity in Kir channels. A tale of an active and a silent PIP2 site in the N terminus.Protein kinase C inhibits ROMK1 channel activity via a phosphatidylinositol 4,5-bisphosphate-dependent mechanism.Subunit stoichiometry of the Kir1.1 channel in proton-dependent gating.Modulation of the Kir7.1 potassium channel by extracellular and intracellular pH.The endosomal trafficking factors CORVET and ESCRT suppress plasma membrane residence of the renal outer medullary potassium channel (ROMK).Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators.Inwardly Rectifying K+ Currents in Cultured Oligodendrocytes from Rat Optic Nerve are Insensitive to pH.Protein kinase C mediated pH(i)-regulation of ROMK1 channels via a phosphatidylinositol-4,5-bisphosphate-dependent mechanism.Phosphatidylinositol-4,5-bisphosphate (PIP2) regulation of strong inward rectifier Kir2.1 channels: multilevel positive cooperativity.
P2860
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P2860
Phosphatidylinositol 4,5-bisphosphate and intracellular pH regulate the ROMK1 potassium channel via separate but interrelated mechanisms.
description
2000 nî lūn-bûn
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2000年の論文
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2000年学术文章
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name
Phosphatidylinositol 4,5-bisph ...... e but interrelated mechanisms.
@en
Phosphatidylinositol 4,5-bisph ...... e but interrelated mechanisms.
@nl
type
label
Phosphatidylinositol 4,5-bisph ...... e but interrelated mechanisms.
@en
Phosphatidylinositol 4,5-bisph ...... e but interrelated mechanisms.
@nl
prefLabel
Phosphatidylinositol 4,5-bisph ...... e but interrelated mechanisms.
@en
Phosphatidylinositol 4,5-bisph ...... e but interrelated mechanisms.
@nl
P2093
P2860
P356
P1476
Phosphatidylinositol 4,5-bisph ...... e but interrelated mechanisms.
@en
P2093
P2860
P304
10182-10189
P356
10.1074/JBC.275.14.10182
P407
P577
2000-04-01T00:00:00Z