about
sameAs
P688
Linkage of ATM to cell cycle regulation by the Chk2 protein kinaseA human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphataseHeterozygous germ line hCHK2 mutations in Li-Fraumeni syndromeThe ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesisTelomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblastsTrans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchangeChk2 activates E2F-1 in response to DNA damageThe E3 ligase RNF8 regulates KU80 removal and NHEJ repairPriming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damageThe CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cellsEndoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3betaActivation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sitesPML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genesRegulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damagePARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair
P921
Q22008502-1C63C61A-1CD4-4817-B802-BED73185BAC3Q22008669-6ACB497D-2493-4FD0-BD20-0418AF1CBE17Q22011001-E0383BD0-9736-454D-B000-0D31BAC3706EQ24291114-52784DBF-C01B-4455-B020-2BCFE9726043Q24293520-C63566C5-3C79-4F42-BC3D-82129AF877B6Q24294537-CAB02440-84D7-4869-BA36-524FED5C90BDQ24294605-F5AE4A4D-0957-487E-BD7A-AF9A6291EFB3Q24300634-5A47D027-E138-4FC7-AC3C-57BE34763F1AQ24302499-76F2BFFA-D7C7-4FCA-85BA-923C4C77B2BAQ24304884-9CDF5114-41F0-4748-9AB8-901C7571E6D5Q24305557-E7E59335-53AF-404A-826D-9DFEF0D3F86EQ24306430-D0B7587D-B952-49A4-B225-BAB4ECF03041Q24309323-1EF82B61-D5DE-4229-866D-5D3B24623187Q24313485-2CC368BD-ED8D-45C8-A1C4-686BD9E1D7BFQ24314901-4BA6E137-26C3-4177-AB24-252902F2DE34Q24315969-17684BE8-7BBF-4127-98AD-589F88FD0D9AQ24320698-A075D71B-2C96-4C53-8BF4-48BB8A99C01BQ24337719-4343360D-E652-49D7-94CE-79177DFD4469
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in CHEK2
@nl
protèin
@ace
protéine
@fr
بروتين في الإنسان العاقل
@ar
name
CHEK2
@de
CHEK2
@es
CHEK2
@fr
CHEK2
@nl
CHEK2
@pl
CHEK2
@uk
Checkpoint kinase 2
@en
type
label
CHEK2
@de
CHEK2
@es
CHEK2
@fr
CHEK2
@nl
CHEK2
@pl
CHEK2
@uk
Checkpoint kinase 2
@en
altLabel
CHEK2
@en
CHK2 checkpoint homolog
@en
CHK2
@pl
Hucds1
@en
cds1 homolog
@en
checkpoint-like protein CHK2
@en
hCds1
@en
serine/threonine-protein kinase Chk2
@en
prefLabel
CHEK2
@de
CHEK2
@es
CHEK2
@fr
CHEK2
@nl
CHEK2
@pl
CHEK2
@uk
Checkpoint kinase 2
@en
P527
P637
P638
P680
P681
P682
P705
P352
P486
P637
P646
P2888
P31
P352
P486
P527
P637
NP_001005735
NP_001244316
NP_001336885
XP_006724177
XP_006724179
XP_011528141
XP_011528142
XP_011528143
P638
P646
/m/02qf66r
P680
P682
P702
P703
P705
ENSP00000329012
ENSP00000372006
ENSP00000372023
ENSP00000381099
ENSP00000384835
ENSP00000384919
ENSP00000385747
ENSP00000386087
ENSP00000387451
ENSP00000390244