Premature death of TDP-43 (A315T) transgenic mice due to gastrointestinal complications prior to development of full neurological symptoms of amyotrophic lateral sclerosis.
about
From animal models to human disease: a genetic approach for personalized medicine in ALSConverging mechanisms in ALS and FTD: disrupted RNA and protein homeostasisThe bowel and beyond: the enteric nervous system in neurological disordersAbnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models.Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice.Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS.Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis.Mutant TDP-43 deregulates AMPK activation by PP2A in ALS models.Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS.A high-fat jelly diet restores bioenergetic balance and extends lifespan in the presence of motor dysfunction and lumbar spinal cord motor neuron loss in TDP-43A315T mutant C57BL6/J mice.Increased metal content in the TDP-43(A315T) transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.Amyotrophic lateral sclerosis--a model of corticofugal axonal spread.Changes in the endocannabinoid signaling system in CNS structures of TDP-43 transgenic mice: relevance for a neuroprotective therapy in TDP-43-related disorders.FTD and ALS--translating mouse studies into clinical trials.Advances in the Development of Disease-Modifying Treatments for Amyotrophic Lateral Sclerosis.Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS.TDP-43/FUS in motor neuron disease: Complexity and challenges.Extra-motor abnormalities in amyotrophic lateral sclerosis: another layer of heterogeneity.ALS/FTLD: experimental models and reality.Motoneuron Disease: Basic Science.Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice.Are Astrocytes the Predominant Cell Type for Activation of Nrf2 in Aging and Neurodegeneration?Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model.Riluzole does not improve lifespan or motor function in three ALS mouse models.TDP-43 modification in the hSOD1(G93A) amyotrophic lateral sclerosis mouse model.Hypothalamic Alterations in Neurodegenerative Diseases and Their Relation to Abnormal Energy Metabolism.Optimizing mouse models of neurodegenerative disorders: are therapeutics in sight?Theme 14 Therapeutic StrategiesDifferential Neurotoxicity Related to Tetracycline Transactivator and TDP-43 Expression in Conditional TDP-43 Mouse Model of Frontotemporal Lobar DegenerationFrom Mouse Models to Human Disease: An Approach for Amyotrophic Lateral Sclerosis
P2860
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P2860
Premature death of TDP-43 (A315T) transgenic mice due to gastrointestinal complications prior to development of full neurological symptoms of amyotrophic lateral sclerosis.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
@zh-hant
name
Premature death of TDP-43 (A31 ...... amyotrophic lateral sclerosis.
@en
Premature death of TDP-43
@nl
type
label
Premature death of TDP-43 (A31 ...... amyotrophic lateral sclerosis.
@en
Premature death of TDP-43
@nl
prefLabel
Premature death of TDP-43 (A31 ...... amyotrophic lateral sclerosis.
@en
Premature death of TDP-43
@nl
P2093
P2860
P356
P1476
Premature death of TDP-43 (A31 ...... amyotrophic lateral sclerosis.
@en
P2093
Leah Hennings
Mahmoud Kiaei
Marzieh Panahi
Mohammad A Esmaeili
Shilpi Yadav
P2860
P356
10.1111/IEP.12006
P577
2013-02-01T00:00:00Z