GSK3beta activity modifies the localization and function of presenilin 1. - Wikidata - wikimedia - TriplyDB

GSK3beta activity modifies the localization and function of presenilin 1.

GSK3beta activity modifies the localization and function of presenilin 1.

http://www.wikidata.org/entity/Q51798675

about

Glycogen synthase kinase 3 beta positively regulates Notch signaling in vascular smooth muscle cells: role in cell proliferation and survival Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes.Early life nutrient restriction impairs blood-brain metabolic profile and neurobehavior predisposing to Alzheimer's disease with aging.Loss of Hsp110 leads to age-dependent tau hyperphosphorylation and early accumulation of insoluble amyloid beta.Differential neuregulin 1 cleavage in the prefrontal cortex and hippocampus in schizophrenia and bipolar disorder: preliminary findings N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: implications for neurodegeneration in Alzheimer disease Presenilin-1 processing of ErbB4 in fetal type II cells is necessary for control of fetal lung maturation.Function and comorbidities of apolipoprotein e in Alzheimer's disease.N-butylidenephthalide attenuates Alzheimer's disease-like cytopathy in Down syndrome induced pluripotent stem cell-derived neurons Functions of GSK-3 Signaling in Development of the Nervous System.High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation.p120-catenin is a key component of the cadherin-gamma-secretase supercomplex.Presenilin: RIP and beyond.GSK-3 is a master regulator of neural progenitor homeostasis.Diets involved in PPAR and PI3K/AKT/PTEN pathway may contribute to neuroprotection in a traumatic brain injury.GSK-3β, a pivotal kinase in Alzheimer disease.The brain-tumor related protein podoplanin regulates synaptic plasticity and hippocampus-dependent learning and memory.BRI2 ectodomain affects Aβ42 fibrillation and tau truncation in human neuroblastoma cells.A ubiquitin-binding CUE domain in presenilin-1 enables interaction with K63-linked polyubiquitin chains.N-cadherin-based adhesion enhances Abeta release and decreases Abeta42/40 ratio.Gain of function by phosphorylation in Presenilin 1-mediated regulation of insulin signaling.Regulated intramembrane proteolysis: emergent role in cell signalling pathways.The Presenilin loop region is essential for Glycogen synthase kinase 3 beta mediated functions on motor proteins during axonal transport.

P2860

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P2860

GSK3beta activity modifies the localization and function of presenilin 1.

http://www.wikidata.org/entity/Q51798675

description

2007 nî lūn-bûn

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2007年の論文

@ja

2007年学术文章

@wuu

2007年学术文章

@zh

2007年学术文章

@zh-cn

2007年学术文章

@zh-hans

2007年学术文章

@zh-my

2007年学术文章

@zh-sg

2007年學術文章

@yue

2007年學術文章

@zh-hant

name

GSK3beta activity modifies the localization and function of presenilin 1.

@en

GSK3beta activity modifies the localization and function of presenilin 1.

@nl

type

label

GSK3beta activity modifies the localization and function of presenilin 1.

@en

GSK3beta activity modifies the localization and function of presenilin 1.

@nl

prefLabel

GSK3beta activity modifies the localization and function of presenilin 1.

@en

GSK3beta activity modifies the localization and function of presenilin 1.

@nl

P1433

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P1433

Journal of Biological Chemistry

P1476

GSK3beta activity modifies the localization and function of presenilin 1

@en

P2093

Akira Kuzuya

http://www.w3.org/2001/XMLSchema#string

Ayae Kinoshita

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Kengo Uemura

http://www.w3.org/2001/XMLSchema#string

Koichi Ando

http://www.w3.org/2001/XMLSchema#string

Nobuhisa Aoyagi

http://www.w3.org/2001/XMLSchema#string

Shun Shimohama

http://www.w3.org/2001/XMLSchema#string

P2860

Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

Cadherin regulates dendritic spine morphogenesis

Depolarization drives beta-Catenin into neuronal spines promoting changes in synaptic structure and function

P304

15823-15832

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scholarly article

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10.1074/JBC.M610708200

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21

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282

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Yoshiharu Shimozono

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2007-03-27T00:00:00Z

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P698

17389597

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