Biological activities, mechanisms of action and biomedical prospect of the antitumor ether phospholipid ET-18-OCH(3) (edelfosine), a proapoptotic agent in tumor cells.
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Inhibition of Granulomatous Inflammation and Prophylactic Treatment of Schistosomiasis with a Combination of Edelfosine and PraziquantelIn vitro and in vivo anti-schistosomal activity of the alkylphospholipid analog edelfosineIn vitro and in vivo efficacy of ether lipid edelfosine against Leishmania spp. and SbV-resistant parasitesPhospholipase C and myosin light chain kinase inhibition define a common step in actin regulation during cytokinesisSynthetic glycosidated phospholipids induce apoptosis through activation of FADD, caspase-8 and the mitochondrial death pathway.Lipid raft-targeted therapy in multiple myeloma.The SK3/K(Ca)2.3 potassium channel is a new cellular target for edelfosine.Involvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondria.Endoplasmic reticulum targeting in Ewing's sarcoma by the alkylphospholipid analog edelfosineMiltefosine in the treatment of leishmaniasis: Clinical evidence for informed clinical risk management.Drug uptake, lipid rafts, and vesicle trafficking modulate resistance to an anticancer lysophosphatidylcholine analogue in yeastEdelfosine Promotes Apoptosis in Androgen-Deprived Prostate Tumors by Increasing ATF3 and Inhibiting Androgen Receptor ActivityBacteria induce prolonged PMN survival via a phosphatidylcholine-specific phospholipase C- and protein kinase C-dependent mechanism.Glycosidated phospholipids: uncoupling of signalling pathways at the plasma membrane.PI3K and Akt as molecular targets for cancer therapy: current clinical outcomes.Influence of platelet-activating factor, lyso-platelet-activating factor and edelfosine on Langmuir monolayers imitating plasma membranes of cell lines differing in susceptibility to anti-cancer treatment: the effect of plasmalogen level.Lipid rafts and clusters of apoptotic signaling molecule-enriched rafts in cancer therapy.Lipids and cell death in yeast.Lipid rafts and raft-mediated supramolecular entities in the regulation of CD95 death receptor apoptotic signaling.The alkyllysophospholipid edelfosine enhances TRAIL-mediated apoptosis in gastric cancer cells through death receptor 5 and the mitochondrial pathway.Caenorhabditis elegans as a platform to study the mechanism of action of synthetic antitumor lipidsAntitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum.Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine.Miltefosine (hexadecylphosphocholine) inhibits cytochrome c oxidase in Leishmania donovani promastigotes.On the mechanism of alkylphosphocholine (APC)-induced apoptosis in tumour cells.Combination of the anti-tumour cell ether lipid edelfosine with sterols abolishes haemolytic side effects of the drug.Necroptosis is associated with low procaspase-8 and active RIPK1 and -3 in human glioma cells.Interactions of alkylphosphocholines with model membranes-the Langmuir monolayer study.The phenyltetraene lysophospholipid analog PTE-ET-18-OMe as a fluorescent anisotropy probe of liquid ordered membrane domains (lipid rafts) and ceramide-rich membrane domains.Alteration of plasma membrane organization by an anticancer lysophosphatidylcholine analogue induces intracellular acidification and internalization of plasma membrane transporters in yeast.Intracellular triggering of Fas aggregation and recruitment of apoptotic molecules into Fas-enriched rafts in selective tumor cell apoptosisLipid raft-mediated Akt signaling as a therapeutic target in mantle cell lymphomaLipid raft involvement in yeast cell growth and death.Phospholipase C signaling tonically represses basal atrial natriuretic factor secretion from the atria of the heart.Influence of cancerostatic perifosine on membrane fluidity of liposomes and different cell lines as measured by electron paramagnetic resonance.Critical and distinct roles for key RET tyrosine docking sites in renal development.Lipid rafts, death receptors and CASMERs: new insights for cancer therapy.Synthesis of Bioconjugate Sesterterpenoids with Phospholipids and Polyunsaturated Fatty Acids.Cytotoxicity of an Anti-cancer Lysophospholipid through Selective Modification of Lipid Raft CompositionDifferential Targets and Subcellular Localization of Antitumor Alkyl-lysophospholipid in LeukemicVersusSolid Tumor Cells
P2860
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P2860
Biological activities, mechanisms of action and biomedical prospect of the antitumor ether phospholipid ET-18-OCH(3) (edelfosine), a proapoptotic agent in tumor cells.
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Biological activities, mechani ...... poptotic agent in tumor cells.
@ast
Biological activities, mechani ...... poptotic agent in tumor cells.
@en
Biological activities, mechani ...... poptotic agent in tumor cells.
@nl
type
label
Biological activities, mechani ...... poptotic agent in tumor cells.
@ast
Biological activities, mechani ...... poptotic agent in tumor cells.
@en
Biological activities, mechani ...... poptotic agent in tumor cells.
@nl
prefLabel
Biological activities, mechani ...... poptotic agent in tumor cells.
@ast
Biological activities, mechani ...... poptotic agent in tumor cells.
@en
Biological activities, mechani ...... poptotic agent in tumor cells.
@nl
P356
P1476
Biological activities, mechani ...... poptotic agent in tumor cells.
@en
P2093
Faustino Mollinedo
P304
P356
10.2174/1389200023337225
P407
P577
2002-10-01T00:00:00Z