Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice. - Wikidata - wikimedia - TriplyDB

Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice.

Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice.

http://www.wikidata.org/entity/Q51964751

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Amyloid-beta Alzheimer targets - protein processing, lipid rafts, and amyloid-beta pores Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer's disease mouse model.Imbalance in fatty-acid-chain length of gangliosides triggers Alzheimer amyloid deposition in the precuneus Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice Cross-talk of membrane lipids and Alzheimer-related proteins.Vitamin C deficiency increases basal exploratory activity but decreases scopolamine-induced activity in APP/PSEN1 transgenic mice Intracranial V. cholerae sialidase protects against excitotoxic neurodegeneration Ganglioside metabolism in a transgenic mouse model of Alzheimer's disease: expression of Chol-1α antigens in the brain.Amyloid precursor protein (APP) mediated regulation of ganglioside homeostasis linking Alzheimer's disease pathology with ganglioside metabolism.Abnormal vibrissa-related behavior and loss of barrel field inhibitory neurons in 5xFAD transgenics.Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models The pathological roles of ganglioside metabolism in Alzheimer's disease: effects of gangliosides on neurogenesis.Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits.Differential proteomic and behavioral effects of long-term voluntary exercise in wild-type and APP-overexpressing transgenics.Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues Linking lipids to Alzheimer's disease: cholesterol and beyond.Effects of membrane lipids on the activity and processivity of purified γ-secretase Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease--a review Brain gangliosides of a transgenic mouse model of Alzheimer's disease with deficiency in GD3-synthase: expression of elevated levels of a cholinergic-specific ganglioside, GT1aα Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice.Vitamin C reduces spatial learning deficits in middle-aged and very old APP/PSEN1 transgenic and wild-type mice.Functional roles of gangliosides in neurodevelopment: an overview of recent advances.Sphingolipids and gangliosides of the nervous system in membrane function and dysfunction.APP Function and Lipids: A Bidirectional Link.Intravenous ascorbate improves spatial memory in middle-aged APP/PSEN1 and wild type mice.Structures, biosynthesis, and functions of gangliosides--an overview.The role of APP proteolytic processing in lipid metabolism.Implications for the mammalian sialidases in the physiopathology of skeletal muscle Endo-lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?Omega-3 fatty acids, lipids and apoE lipidation in Alzheimer's disease: a rationale for multi-nutrient dementia prevention.Cytotoxic effects of G(M1) ganglioside and amyloid β-peptide on mouse embryonic neural stem cells.GD3 accumulation in cell surface lipid rafts prior to mitochondrial targeting contributes to amyloid-β-induced apoptosis.Candidate genes in ocular dominance plasticity Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing Characterization of AD-like phenotype in aged APPSwe/PS1dE9 mice.Histone acetylation-mediated glycosyltransferase gene regulation in mouse brain during development.Effects of amyloid β-peptides and gangliosides on mouse neural stem cells.Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks.Targeted deletion of GD3 synthase protects against MPTP-induced neurodegeneration.

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Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice.

http://www.wikidata.org/entity/Q51964751

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年學術文章

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name

Elimination of GD3 synthase im ...... laque load in transgenic mice.

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Elimination of GD3 synthase im ...... laque load in transgenic mice.

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type

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Elimination of GD3 synthase im ...... laque load in transgenic mice.

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Elimination of GD3 synthase im ...... laque load in transgenic mice.

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prefLabel

Elimination of GD3 synthase im ...... laque load in transgenic mice.

@en

Elimination of GD3 synthase im ...... laque load in transgenic mice.

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J.NEUROBIOLAGING.2007.12.022

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Neurobiology of Aging

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Elimination of GD3 synthase im ...... plaque load in transgenic mice

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Aleksandra Bruchey

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Alexandra Bernardo

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Jiali Zhao

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L Jackson Roberts

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Meghan McCord

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Robert K Yu

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Sean S Davies

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Toshio Ariga

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Yasuji Matsuoka

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1777-1791

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scholarly article

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10.1016/J.NEUROBIOLAGING.2007.12.022

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11

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Fiona E. Harrison

Michael P. McDonald

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2008-02-06T00:00:00Z

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