Conditional deletion of Shp2 tyrosine phosphatase in thymocytes suppresses both pre-TCR and TCR signals.
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A THEMIS:SHP1 complex promotes T-cell survivalThe PD1:PD-L1/2 Pathway from Discovery to Clinical ImplementationThe protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functionsSHP-1 and SHP-2 in T cells: two phosphatases functioning at many levelsQuantitative analysis of intracellular communication and signaling errors in signaling networksA Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation.Prolactin receptor-integrin cross-talk mediated by SIRPα in breast cancer cells.SHP2 is a target of the immunosuppressant tautomycetin.Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutationsDeletion of Snai2 and Snai3 results in impaired physical development compounded by lymphocyte deficiency.A quantitative assessment of costimulation and phosphatase activity on microclusters in early T cell signaling.Protein Tyrosine Phosphatase SHP-2 (PTPN11) in Hematopoiesis and Leukemogenesis.Leukocyte-associated Ig-like receptor-1-deficient mice have an altered immune cell phenotype.T cell activation is reduced by the catalytically inactive form of protein tyrosine phosphatase SHP-2Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in miceProtein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b DegradationShp2 plays an important role in acute cigarette smoke-mediated lung inflammationInhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus.Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammationLoss of SHP-2 activity in CD4+ T cells promotes melanoma progression and metastasisBlocking initial infiltration of pioneer CD8(+) T-cells into the CNS via inhibition of SHP-2 ameliorates experimental autoimmune encephalomyelitis in mice.A VISTA on PD-1H.Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity.Targeting protein tyrosine phosphatase SHP2 for therapeutic intervention.THEMIS: Two Models, Different Thresholds.Modeling RASopathies with Genetically Modified Mouse Models.Src homology 2-containing protein tyrosine phosphatase-2 acts as a negative regulator for MUC5AC transcription via the inhibition of the ERK1/2 MAPK signalling pathway in the airway.An adenoviral vector encoding dominant negative Cbl lowers the threshold for T cell activation in post-thymic T cells.Conditional deletion of PTEN in peripheral T cells augments TCR-mediated activation but does not abrogate CD28 dependency or prevent anergy induction.Ptpn11 Deletion in CD4+ Cells Does Not Affect T Cell Development and Functions but Causes Cartilage Tumors in a T Cell-Independent Manner.Fine-Tuning of Optimal TCR Signaling in Tumor-Redirected CD8 T Cells by Distinct TCR Affinity-Mediated Mechanisms.A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy.Protein Tyrosine Phosphatases: Regulators of CD4 T Cells in Inflammatory Bowel Disease
P2860
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P2860
Conditional deletion of Shp2 tyrosine phosphatase in thymocytes suppresses both pre-TCR and TCR signals.
description
2006 nî lūn-bûn
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2006年の論文
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2006年学术文章
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2006年学术文章
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2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
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2006年学术文章
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2006年學術文章
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2006年學術文章
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name
Conditional deletion of Shp2 t ...... both pre-TCR and TCR signals.
@en
Conditional deletion of Shp2 t ...... both pre-TCR and TCR signals.
@nl
type
label
Conditional deletion of Shp2 t ...... both pre-TCR and TCR signals.
@en
Conditional deletion of Shp2 t ...... both pre-TCR and TCR signals.
@nl
prefLabel
Conditional deletion of Shp2 t ...... both pre-TCR and TCR signals.
@en
Conditional deletion of Shp2 t ...... both pre-TCR and TCR signals.
@nl
P2093
P1476
Conditional deletion of Shp2 t ...... both pre-TCR and TCR signals.
@en
P2093
Eric E Zhang
Gen-Sheng Feng
Thanh V Nguyen
P304
P356
10.4049/JIMMUNOL.177.9.5990
P407
P577
2006-11-01T00:00:00Z