Translational suppression by trinucleotide repeat expansion at FMR1.
about
Novel autism subtype-dependent genetic variants are revealed by quantitative trait and subphenotype association analyses of published GWAS dataThe fragile-X premutation: a maturing perspective.Comparative genomics and molecular dynamics of DNA repeats in eukaryotesFragile X (CGG)n repeats induce a transcriptional repression in cis upon a linked promoter: evidence for a chromatin mediated effectFacile FMR1 mRNA structure regulation by interruptions in CGG repeatsDysregulation and restoration of translational homeostasis in fragile X syndromeFrom genes to environment: using integrative genomics to build a "systems-level" understanding of autism spectrum disordersChannelopathy pathogenesis in autism spectrum disordersRNA-mediated neurodegeneration in fragile X-associated tremor/ataxia syndromeHIV: cell binding and entryInteraction of the transcription factors USF1, USF2, and alpha -Pal/Nrf-1 with the FMR1 promoter. Implications for Fragile X mental retardation syndromeThe fragile X gene and its functionRoles of fragile X mental retardation protein in dopaminergic stimulation-induced synapse-associated protein synthesis and subsequent alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-4-propionate (AMPA) receptor internalizationNormal Performance of Fmr1 Mice on a Touchscreen Delayed Nonmatching to Position Working Memory TaskStem cells and modeling of autism spectrum disorders.Impaired sensorimotor gating in Fmr1 knock out and Fragile X premutation model mice.Identifying intrinsic and extrinsic determinants that regulate internal initiation of translation mediated by the FMR1 5' leader.Molecular and cellular genetics of fragile X syndrome.Fragile X-Associated Tremor/Ataxia Syndrome: From Molecular Pathogenesis to Development of Therapeutics.Mosaicism for the fragile X syndrome full mutation and deletions within the CGG repeat of the FMR1 gene.Variable FMR1 gene methylation of large expansions leads to variable phenotype in three males from one fragile X family.Unusual mutations in high functioning fragile X males: apparent instability of expanded unmethylated CGG repeats.Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome.Repeat associated non-ATG translation initiation: one DNA, two transcripts, seven reading frames, potentially nine toxic entities!Examination of FMR1 transcript and protein levels among 74 premutation carriers.Testing the FMR1 promoter for mosaicism in DNA methylation among CpG sites, strands, and cells in FMR1-expressing males with fragile X syndrome.Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain.Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome.The clinical significance of fragile sites on human chromosomes.Hypomethylation of an expanded FMR1 allele is not associated with a global DNA methylation defect.Elevated levels of FMR1 mRNA in carrier males: a new mechanism of involvement in the fragile-X syndrome.Cerebral protein synthesis in a knockin mouse model of the fragile X premutation.Reduced FMR1 mRNA translation efficiency in fragile X patients with premutations.Deficits in LTP induction by 5-HT2A receptor antagonist in a mouse model for fragile X syndromeFragile X mental retardation protein expression in Alzheimer's diseaseExcessive astrocyte-derived neurotrophin-3 contributes to the abnormal neuronal dendritic development in a mouse model of fragile X syndrome.RNA structure of trinucleotide repeats associated with human neurological diseases.Initiation of translation of the FMR1 mRNA Occurs predominantly through 5'-end-dependent ribosomal scanningCognitive Aspects of Fragile X syndrome.Fragile X mental retardation protein regulates heterosynaptic plasticity in the hippocampus
P2860
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P2860
Translational suppression by trinucleotide repeat expansion at FMR1.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Translational suppression by trinucleotide repeat expansion at FMR1.
@en
Translational suppression by trinucleotide repeat expansion at FMR1.
@nl
type
label
Translational suppression by trinucleotide repeat expansion at FMR1.
@en
Translational suppression by trinucleotide repeat expansion at FMR1.
@nl
prefLabel
Translational suppression by trinucleotide repeat expansion at FMR1.
@en
Translational suppression by trinucleotide repeat expansion at FMR1.
@nl
P2093
P356
P1433
P1476
Translational suppression by trinucleotide repeat expansion at FMR1.
@en
P2093
Chastain JL
Eberhart D
P304
P356
10.1126/SCIENCE.7732383
P407
P577
1995-05-01T00:00:00Z