Development of mice with osteoblast-specific connexin43 gene deletion.
about
Osteocytes: master orchestrators of boneDissection of platelet and myeloid cell defects by conditional targeting of the beta3-integrin subunit.Enhanced osteoclastic resorption and responsiveness to mechanical load in gap junction deficient bone.Inhibition of GSK-3β rescues the impairments in bone formation and mechanical properties associated with fracture healing in osteoblast selective connexin 43 deficient mice.Evidence for the role of connexin 43-mediated intercellular communication in the process of intracortical bone resorption via osteocytic osteolysisRoles of gap junctions and hemichannels in bone cell functions and in signal transmission of mechanical stress.Deletion of connexin43 in osteoblasts/osteocytes leads to impaired muscle formation in mice.Connexin 43 deficiency desensitizes bone to the effects of mechanical unloading through modulation of both arms of bone remodelingRole of connexins and pannexins during ontogeny, regeneration, and pathologies of boneCell-cell communication in the osteoblast/osteocyte lineage.Osteoblast and osteocyte-specific loss of Connexin43 results in delayed bone formation and healing during murine fracture healingGap Junctions and Biophysical Regulation of Bone CellsConnexin 43 deficiency attenuates loss of trabecular bone and prevents suppression of cortical bone formation during unloading.Attenuated response to in vivo mechanical loading in mice with conditional osteoblast ablation of the connexin43 gene (Gja1).Expressing connexin 43 in breast cancer cells reduces their metastasis to lungs.Shifting paradigms on the role of connexin43 in the skeletal response to mechanical load.Gap junctional communication in human osteoclasts in vitro and in vivoODDD-linked Cx43 mutants reduce endogenous Cx43 expression and function in osteoblasts and inhibit late stage differentiation.Functional characterization of oculodentodigital dysplasia-associated Cx43 mutants.
P2860
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P2860
Development of mice with osteoblast-specific connexin43 gene deletion.
description
2003 nî lūn-bûn
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2003年の論文
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2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
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2003年學術文章
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name
Development of mice with osteoblast-specific connexin43 gene deletion.
@en
Development of mice with osteoblast-specific connexin43 gene deletion.
@nl
type
label
Development of mice with osteoblast-specific connexin43 gene deletion.
@en
Development of mice with osteoblast-specific connexin43 gene deletion.
@nl
prefLabel
Development of mice with osteoblast-specific connexin43 gene deletion.
@en
Development of mice with osteoblast-specific connexin43 gene deletion.
@nl
P2093
P2860
P1476
Development of mice with osteoblast-specific connexin43 gene deletion.
@en
P2093
Charles H M Castro
Joseph P Stains
Klaus Willecke
Martin Theis
Roberto Civitelli
Sharmin Sheikh
Vera Lucia Szejnfeld
P2860
P304
P356
10.1080/CAC.10.4-6.445.450
P577
2003-07-01T00:00:00Z