A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity.
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Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers.Endogenous DNA double-strand breaks: production, fidelity of repair, and induction of cancerA target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancerGuido Pontecorvo ("Ponte"): a centenary memoirBeta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumoursA common role for various human truncated adenomatous polyposis coli isoforms in the control of beta-catenin activity and cell proliferationAneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and humanAlpha-catenin is essential in intestinal adenoma formationMlh1 mediates tissue-specific regulation of mitotic recombinationPPARdelta status and mismatch repair mediated neoplasia in the mouse intestine.Polyclonality of familial murine adenomas: analyses of mouse chimeras with low tumor multiplicity suggest short-range interactionsGenetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice.Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesisThe utility of Apc-mutant rats in modeling human colon cancer.KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis.A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesisClusterin as a biomarker in murine and human intestinal neoplasiaMonoallelic silencing and haploinsufficiency in early murine intestinal neoplasms.The modifier of Min 2 (Mom2) locus: embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression.Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18.c-Myc-dependent formation of Robertsonian translocation chromosomes in mouse cells.Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis.Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulationTumor regionality in the mouse intestine reflects the mechanism of loss of Apc function.Polyclonal tumors in the mammalian intestine: are interactions among multiple initiated clones necessary for tumor initiation, growth, and progression?The pleiotropic phenotype of Apc mutations in the mouse: allele specificity and effects of the genetic background.Widespread hyperplasia induced by transgenic TGFalpha in ApcMin mice is associated with only regional effects on tumorigenesis.Transformation of epithelial cells through recruitment leads to polyclonal intestinal tumorsHigh rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation.Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway.Lack of interferon-γ receptor results in a microenvironment favorable for intestinal tumorigenesis.APC and its modifiers in colon cancer.Somatic recombination in adult tissues: What is there to learn?Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients.Loss of single immunoglobulin interlukin-1 receptor-related molecule leads to enhanced colonic polyposis in Apc(min) mice.Restricted gene flow at specific parts of the shrew genome in chromosomal hybrid zones.Chromosomal rearrangements do not seem to affect the gene flow in hybrid zones between karyotypic races of the common shrew (Sorex araneus).Chromosomal rearrangements and genetic structure at different evolutionary levels of the Sorex araneus group.Somatic recombination redux.Chromosomal inversions as a hidden disease-modifying factor for somatic recombination phenotypes.
P2860
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P2860
A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity.
description
2002 nî lūn-bûn
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2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
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2002年學術文章
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name
A Robertsonian translocation s ...... way to loss of heterozygosity.
@en
A Robertsonian translocation s ...... way to loss of heterozygosity.
@nl
type
label
A Robertsonian translocation s ...... way to loss of heterozygosity.
@en
A Robertsonian translocation s ...... way to loss of heterozygosity.
@nl
prefLabel
A Robertsonian translocation s ...... way to loss of heterozygosity.
@en
A Robertsonian translocation s ...... way to loss of heterozygosity.
@nl
P2860
P356
P1433
P1476
A Robertsonian translocation s ...... way to loss of heterozygosity.
@en
P2093
Kevin M Haigis
William F Dove
P2860
P2888
P356
10.1038/NG1055
P407
P577
2002-11-25T00:00:00Z