FANCD2 binds MCM proteins and controls replisome function upon activation of s phase checkpoint signaling.
about
Interplay between Fanconi anemia and homologous recombination pathways in genome integrityFunctions and regulation of the multitasking FANCM family of DNA motor proteinsReplication stress: getting back on trackUbiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instabilityPapillomavirus genomes associate with BRD4 to replicate at fragile sites in the host genome.A concomitant loss of dormant origins and FANCC exacerbates genome instability by impairing DNA replication fork progression.CtIP mediates replication fork recovery in a FANCD2-regulated manner.Replication stress by Py-Im polyamides induces a non-canonical ATR-dependent checkpoint response.Rescue from replication stress during mitosis.The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancersRad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells.TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution.Replication Protein A (RPA) deficiency activates the Fanconi anemia DNA repair pathway.FANCD2 influences replication fork processes and genome stability in response to clustered DSBs.FANCD2, FANCJ and BRCA2 cooperate to promote replication fork recovery independently of the Fanconi Anemia core complex.The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription.PTEN regulates RPA1 and protects DNA replication forks.DEK is required for homologous recombination repair of DNA breaks.Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart.Replication stress and cancer: it takes two to tango.FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair.FANCJ is essential to maintain microsatellite structure genome-wide during replication stress.Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA.Endogenous DNA Damage Leads to p53-Independent Deficits in Replicative Fitness in Fetal Murine Fancd2(-/-) Hematopoietic Stem and Progenitor Cells.The Fanconi anemia ID2 complex: dueling saxes at the crossroads.Abro1 maintains genome stability and limits replication stress by protecting replication fork stability.The essential kinase ATR: ensuring faithful duplication of a challenging genome.FANCI-FANCD2 stabilizes the RAD51-DNA complex by binding RAD51 and protects the 5'-DNA end.FANCD2 limits replication stress and genome instability in cells lacking BRCA2.ATR-mediated phosphorylation of FANCI regulates dormant origin firing in response to replication stress.FANCD2-controlled chromatin access of the Fanconi-associated nuclease FAN1 is crucial for the recovery of stalled replication forks.Preventing over-resection by DNA2 helicase/nuclease suppresses repair defects in Fanconi anemia cells.S-phase checkpoint regulations that preserve replication and chromosome integrity upon dNTP depletion.The Role of the Transcriptional Response to DNA Replication Stress.FANCD2 Facilitates Replication through Common Fragile Sites.Dormant origins as a built-in safeguard in eukaryotic DNA replication against genome instability and disease development.RNA Binding Proteins and Genome Integrity.Proteomic Analyses of the Eukaryotic Replication Machinery.The Role of Replication-Associated Repair Factors on R-LoopsSustained E2F-Dependent Transcription Is a Key Mechanism to Prevent Replication-Stress-Induced DNA Damage.
P2860
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P2860
FANCD2 binds MCM proteins and controls replisome function upon activation of s phase checkpoint signaling.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
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2013年學術文章
@zh-hant
name
FANCD2 binds MCM proteins and ...... s phase checkpoint signaling.
@en
FANCD2 binds MCM proteins and ...... s phase checkpoint signaling.
@nl
type
label
FANCD2 binds MCM proteins and ...... s phase checkpoint signaling.
@en
FANCD2 binds MCM proteins and ...... s phase checkpoint signaling.
@nl
prefLabel
FANCD2 binds MCM proteins and ...... s phase checkpoint signaling.
@en
FANCD2 binds MCM proteins and ...... s phase checkpoint signaling.
@nl
P2093
P50
P1433
P1476
FANCD2 binds MCM proteins and ...... f s phase checkpoint signaling
@en
P2093
Chantal Décaillet
Christian Larroque
Gérald Lossaint
Marion Larroque
Nicole Bec
P304
P356
10.1016/J.MOLCEL.2013.07.023
P577
2013-08-29T00:00:00Z