IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression.
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A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease lociFollicular helper T cells in immunity and systemic autoimmunityThe biological functions of T helper 17 cell effector cytokines in inflammationIL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent mannerEctopic lymphoid follicles: inducible centres for generating antigen-specific immune responses within tissuesLinking susceptibility genes and pathogenesis mechanisms using mouse models of systemic lupus erythematosusInflammatory cytokines in systemic lupus erythematosusFollicular Helper T Cells in Systemic Lupus Erythematosus: Why Should They Be Considered as Interesting Therapeutic Targets?Drug repositioning in SLE: crowd-sourcing, literature-mining and Big Data analysis.The MRL/lpr mouse strain as a model for neuropsychiatric systemic lupus erythematosus.Elevated interleukin-21 correlated to Th17 and Th1 cells in patients with immune thrombocytopenia.Pathogenesis of human systemic lupus erythematosus: recent advances.Increased frequency of circulating IL-21 producing Th-cells in patients with granulomatosis with polyangiitis (GPA).Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliteransCorrelation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeysIn vitro potency, pharmacokinetic profiles, and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupusOlf1/EBF associated zinc finger protein interfered with antinuclear antibody production in patients with systemic lupus erythematosus.Donor CD8 T cell activation is critical for greater renal disease severity in female chronic graft-vs.-host mice and is associated with increased splenic ICOS(hi) host CD4 T cells and IL-21 expressionSystems modeling of the role of interleukin-21 in the maintenance of effector CD4+ T cell responses during chronic Helicobacter pylori infection.Interleukin-21: a new mediator of inflammation in systemic lupus erythematosus.Spontaneous autoimmune dacryoadenitis in aged CD25KO miceA novel murine cytomegalovirus vaccine vector protects against Mycobacterium tuberculosis.An essential role of interleukin-17 receptor signaling in the development of autoimmune glomerulonephritisSystemic autoimmunity and lymphoproliferation are associated with excess IL-7 and inhibited by IL-7Rα blockade.Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice.IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells.Inhibition of aberrant circulating Tfh cell proportions by corticosteroids in patients with systemic lupus erythematosus.Murine models of systemic lupus erythematosusInterleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models.Evaluation of the IL2/IL21, IL2RA and IL2RB genetic variants influence on the endogenous non-anterior uveitis genetic predisposition.IL-21 signaling is critical for the development of type I diabetes in the NOD mouse.Follicular helper T Cells (Tfh) and IL-21 involvement in the pathogenesis of bullous pemphigoid.Beyond regulatory T cells: the potential role for IL-2 to deplete T-follicular helper cells and treat autoimmune diseases.Regulation of human Th9 differentiation by type I interferons and IL-21Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21Key role for IL-21 in experimental autoimmune uveitis.The role of cytokines in the pathogenesis and treatment of systemic lupus erythematosusPhenotypic associations of genetic susceptibility loci in systemic lupus erythematosus.Protein adducts of malondialdehyde and 4-hydroxynonenal contribute to trichloroethene-mediated autoimmunity via activating Th17 cells: dose- and time-response studies in female MRL+/+ mice.IL-21 promotes the pathologic immune response to pneumovirus infection.
P2860
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P2860
IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
IL-21 has a pathogenic role in ...... c reduces disease progression.
@en
IL-21 has a pathogenic role in ...... c reduces disease progression.
@nl
type
label
IL-21 has a pathogenic role in ...... c reduces disease progression.
@en
IL-21 has a pathogenic role in ...... c reduces disease progression.
@nl
prefLabel
IL-21 has a pathogenic role in ...... c reduces disease progression.
@en
IL-21 has a pathogenic role in ...... c reduces disease progression.
@nl
P2093
P1476
IL-21 has a pathogenic role in ...... c reduces disease progression.
@en
P2093
Deborah A Young
Deborah Herber
Kyri Dunussi-Joannopoulos
Mary Collins
Spencer Liang
Thomas P Brown
P304
P356
10.4049/JIMMUNOL.178.6.3822
P407
P577
2007-03-01T00:00:00Z