Molecular mechanism of cAMP modulation of HCN pacemaker channels.
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Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channelsPacemaker channel dysfunction in a patient with sinus node diseaseHypoosmotic cell swelling as a novel mechanism for modulation of cloned HCN2 channels.Functional interactions between A' helices in the C-linker of open CNG channels.Ion Channels in the HeartStructural basis for modulation and agonist specificity of HCN pacemaker channelsC-terminal Movement during Gating in Cyclic Nucleotide-modulated ChannelsStructural Basis for the cAMP-dependent Gating in the Human HCN4 ChannelStructure and stoichiometry of an accessory subunit TRIP8b interaction with hyperpolarization-activated cyclic nucleotide-gated channelsA Mechanism for the Auto-inhibition of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Opening and Its Relief by cAMPThe importance of Ca(2+)-dependent mechanisms for the initiation of the heartbeatMolecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampusDifferent roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channelsRegulation of hyperpolarization-activated HCN channel gating and cAMP modulation due to interactions of COOH terminus and core transmembrane regionsTrafficking and surface expression of hyperpolarization-activated cyclic nucleotide-gated channels in hippocampal neuronsColocalization of hyperpolarization-activated, cyclic nucleotide-gated channel subunits in rat retinal ganglion cellsPostnatal expression pattern of HCN channel isoforms in thalamic neurons: relationship to maturation of thalamocortical oscillations.The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotidesStructures of the Human HCN1 Hyperpolarization-Activated ChannelThe VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic HomeostasisAdenylate cyclase 1 (ADCY1) mutations cause recessive hearing impairment in humans and defects in hair cell function and hearing in zebrafish.Regulation of cell surface expression of functional pacemaker channels by a motif in the B-helix of the cyclic nucleotide-binding domain.Convergent and reciprocal modulation of a leak K+ current and I(h) by an inhalational anaesthetic and neurotransmitters in rat brainstem motoneurones.A reduced mechanical model for cAMP-modulated gating in HCN channelsHCN channels expressed in the inner ear are necessary for normal balance function.Local anesthetic inhibits hyperpolarization-activated cationic currentsCocaine sensitization increases I h current channel subunit 2 (HCN₂) protein expression in structures of the mesocorticolimbic system.Hyperpolarization-activated current (I(h)) in vestibular calyx terminals: characterization and role in shaping postsynaptic events.Dendritic HCN channels shape excitatory postsynaptic potentials at the inner hair cell afferent synapse in the mammalian cochleacAMP Modulation of the cytoplasmic domain in the HCN2 channel investigated by molecular simulations.Structure of the SthK carboxy-terminal region reveals a gating mechanism for cyclic nucleotide-modulated ion channelsReduction of thalamic and cortical Ih by deletion of TRIP8b produces a mouse model of human absence epilepsy.Functional expression of the hyperpolarization-activated, non-selective cation current I(f) in immortalized HL-1 cardiomyocytes.Serotonin modulates spike probability in the axon initial segment through HCN channels.The Ih Channel Gene Promotes Synaptic Transmission and Coordinated Movement in Drosophila melanogaster.Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia.How is the heart rate regulated in the sinoatrial node? Another piece to the puzzleCaveolin-3 associates with and affects the function of hyperpolarization-activated cyclic nucleotide-gated channel 4Association between hyperpolarization-activated channel in interstitial cells of Cajal and gastrointestinal dysmotility induced by malignant ascites.
P2860
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P2860
Molecular mechanism of cAMP modulation of HCN pacemaker channels.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Molecular mechanism of cAMP modulation of HCN pacemaker channels.
@en
Molecular mechanism of cAMP modulation of HCN pacemaker channels.
@nl
type
label
Molecular mechanism of cAMP modulation of HCN pacemaker channels.
@en
Molecular mechanism of cAMP modulation of HCN pacemaker channels.
@nl
prefLabel
Molecular mechanism of cAMP modulation of HCN pacemaker channels.
@en
Molecular mechanism of cAMP modulation of HCN pacemaker channels.
@nl
P2093
P2860
P356
P1433
P1476
Molecular mechanism of cAMP modulation of HCN pacemaker channels
@en
P2093
Siegelbaum SA
Wainger BJ
P2860
P2888
P304
P356
10.1038/35081088
P407
P577
2001-06-01T00:00:00Z
P6179
1042666715