Mechanism by which phosphonoformic acid resistance mutations restore 3'-azido-3'-deoxythymidine (AZT) sensitivity to AZT-resistant HIV-1 reverse transcriptase.
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Alkylglycerol prodrugs of phosphonoformate are potent in vitro inhibitors of nucleoside-resistant human immunodeficiency virus type 1 and select for resistance mutations that suppress zidovudine resistanceN348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistanceThe Role of Nucleotide Excision by Reverse Transcriptase in HIV Drug Resistance.Genotypic testing for human immunodeficiency virus type 1 drug resistance.N348I in HIV-1 reverse transcriptase can counteract the nevirapine-mediated bias toward RNase H cleavage during plus-strand initiation.Drug resistance in non-B subtype HIV-1: impact of HIV-1 reverse transcriptase inhibitors.Comparison of the Mechanisms of Drug Resistance among HIV, Hepatitis B, and Hepatitis C.Relationship between 3'-azido-3'-deoxythymidine resistance and primer unblocking activity in foscarnet-resistant mutants of human immunodeficiency virus type 1 reverse transcriptase.Molecular mechanism by which the K70E mutation in human immunodeficiency virus type 1 reverse transcriptase confers resistance to nucleoside reverse transcriptase inhibitorsA Guide to HIV-1 Reverse Transcriptase and Protease Sequencing for Drug Resistance Studies.Inhibition of HIV-1 reverse transcription: basic principles of drug action and resistance.The Genetic Basis of HIV-1 Resistance to Reverse Transcriptase and Protease Inhibitors.Thymidine analogue resistance suppression by V75I of HIV-1 reverse transcriptase: effects of substituting valine 75 on stavudine excision and discrimination.Mechanism of HIV antiretroviral drugs progress toward drug resistance.The pyrophosphate analogue foscarnet traps the pre-translocational state of HIV-1 reverse transcriptase in a Brownian ratchet model of polymerase translocation.The 3'-azido group is not the primary determinant of 3'-azido-3'-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1.The Y181C substitution in 3'-azido-3'-deoxythymidine-resistant human immunodeficiency virus, type 1, reverse transcriptase suppresses the ATP-mediated repair of the 3'-azido-3'-deoxythymidine 5'-monophosphate-terminated primer.Role of a dipeptide insertion between codons 69 and 70 of HIV-1 reverse transcriptase in the mechanism of AZT resistance.Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet.Hypersusceptibility to substrate analogs conferred by mutations in human immunodeficiency virus type 1 reverse transcriptase.Nucleotide specificity of HIV-1 reverse transcriptases with amino acid substitutions affecting Ala-114.The emergence of different resistance mechanisms toward nucleoside inhibitors is explained by the properties of the wild type HIV-1 reverse transcriptase.Effects of primer-template sequence on ATP-dependent removal of chain-terminating nucleotide analogues by HIV-1 reverse transcriptase.Antiretroviral drug resistance testing in adults infected with human immunodeficiency virus type 1: 2003 recommendations of an International AIDS Society-USA Panel.Sensitive detection of HIV-1 resistance to Zidovudine and impact on treatment outcomes in low- to middle-income countries.Selective Excision of Chain-terminating Nucleotides by HIV-1 Reverse Transcriptase with Phosphonoformate as Substrate
P2860
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P2860
Mechanism by which phosphonoformic acid resistance mutations restore 3'-azido-3'-deoxythymidine (AZT) sensitivity to AZT-resistant HIV-1 reverse transcriptase.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
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name
Mechanism by which phosphonofo ...... t HIV-1 reverse transcriptase.
@en
Mechanism by which phosphonofo ...... ore 3'-azido-3'-deoxythymidine
@nl
type
label
Mechanism by which phosphonofo ...... t HIV-1 reverse transcriptase.
@en
Mechanism by which phosphonofo ...... ore 3'-azido-3'-deoxythymidine
@nl
prefLabel
Mechanism by which phosphonofo ...... t HIV-1 reverse transcriptase.
@en
Mechanism by which phosphonofo ...... ore 3'-azido-3'-deoxythymidine
@nl
P2093
P2860
P356
P1476
Mechanism by which phosphonofo ...... t HIV-1 reverse transcriptase.
@en
P2093
Parniak MA
Sluis-Cremer N
P2860
P304
P356
10.1074/JBC.275.13.9251
P407
P577
2000-03-01T00:00:00Z