Relationship between 3'-azido-3'-deoxythymidine resistance and primer unblocking activity in foscarnet-resistant mutants of human immunodeficiency virus type 1 reverse transcriptase.
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Role of helix P of the human cytomegalovirus DNA polymerase in resistance and hypersusceptibility to the antiviral drug foscarnet.Structural basis of HIV-1 resistance to AZT by excisionStable complexes formed by HIV-1 reverse transcriptase at distinct positions on the primer-template controlled by binding deoxynucleoside triphosphates or foscarnetStructural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir ResistancePurifying selection masks the mutational flexibility of HIV-1 reverse transcriptase.Kinetic pathway of pyrophosphorolysis by a retrotransposon reverse transcriptase.Interactions between HIV-1 reverse transcriptase and the downstream template strand in stable complexes with primer-templateIn vitro activity of structurally diverse nucleoside analogs against human immunodeficiency virus type 1 with the K65R mutation in reverse transcriptaseThe Role of Nucleotide Excision by Reverse Transcriptase in HIV Drug Resistance.Characterization of the polymerase and RNase H activities of human foamy virus reverse transcriptase.The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine.The K65R mutation in human immunodeficiency virus type 1 reverse transcriptase exhibits bidirectional phenotypic antagonism with thymidine analog mutationsInvolvement of novel human immunodeficiency virus type 1 reverse transcriptase mutations in the regulation of resistance to nucleoside inhibitorsInhibition of HIV-1 reverse transcription: basic principles of drug action and resistance.Utilization of a deoxynucleoside diphosphate substrate by HIV reverse transcriptase.DNA polymerases as therapeutic targetsThymidine analogue resistance suppression by V75I of HIV-1 reverse transcriptase: effects of substituting valine 75 on stavudine excision and discrimination.Effects of the Delta67 complex of mutations in human immunodeficiency virus type 1 reverse transcriptase on nucleoside analog excision.The pyrophosphate analogue foscarnet traps the pre-translocational state of HIV-1 reverse transcriptase in a Brownian ratchet model of polymerase translocation.Molecular determinants of multi-nucleoside analogue resistance in HIV-1 reverse transcriptases containing a dipeptide insertion in the fingers subdomain: effect of mutations D67N and T215Y on removal of thymidine nucleotide analogues from blocked DNExploring the role of the α-carboxyphosphonate moiety in the HIV-RT activity of α-carboxy nucleoside phosphonatesChain-terminating dinucleoside tetraphosphates are substrates for DNA polymerization by human immunodeficiency virus type 1 reverse transcriptase with increased activity against thymidine analogue-resistant mutants.Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet.Foscarnet, zidovudine and dolutegravir combination efficacy and tolerability for late stage HIV salvage therapy: A case-series experience.In vitro human immunodeficiency virus type 1 resistance selections with combinations of tenofovir and emtricitabine or abacavir and lamivudine.Hypersusceptibility to substrate analogs conferred by mutations in human immunodeficiency virus type 1 reverse transcriptase.A role of template cleavage in reduced excision of chain-terminating nucleotides by human immunodeficiency virus type 1 reverse transcriptase containing the M184V mutation.Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase.Mechanism of resistance to GS-9148 conferred by the Q151L mutation in HIV-1 reverse transcriptase.Effects of primer-template sequence on ATP-dependent removal of chain-terminating nucleotide analogues by HIV-1 reverse transcriptase.The balance between NRTI discrimination and excision drives the susceptibility of HIV-1 RT mutants K65R, M184V and K65r+M184V.Conjugation of phosphonoacetic acid to nucleobase promotes a mechanism-based inhibition.Selective Excision of Chain-terminating Nucleotides by HIV-1 Reverse Transcriptase with Phosphonoformate as Substrate
P2860
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P2860
Relationship between 3'-azido-3'-deoxythymidine resistance and primer unblocking activity in foscarnet-resistant mutants of human immunodeficiency virus type 1 reverse transcriptase.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Relationship between 3'-azido- ...... type 1 reverse transcriptase.
@ast
Relationship between 3'-azido- ...... type 1 reverse transcriptase.
@en
Relationship between 3'-azido- ...... type 1 reverse transcriptase.
@nl
type
label
Relationship between 3'-azido- ...... type 1 reverse transcriptase.
@ast
Relationship between 3'-azido- ...... type 1 reverse transcriptase.
@en
Relationship between 3'-azido- ...... type 1 reverse transcriptase.
@nl
prefLabel
Relationship between 3'-azido- ...... type 1 reverse transcriptase.
@ast
Relationship between 3'-azido- ...... type 1 reverse transcriptase.
@en
Relationship between 3'-azido- ...... type 1 reverse transcriptase.
@nl
P2093
P2860
P1433
P1476
Relationship between 3'-azido- ...... type 1 reverse transcriptase.
@en
P2093
Dianna Zonarich
Eric Pendarvis
Holly Z Bazmi
John W Mellors
Peter R Meyer
Rahul R Chopra
Suzanne E Matsuura
Walter A Scott
P2860
P304
P356
10.1128/JVI.77.11.6127-6137.2003
P407
P577
2003-06-01T00:00:00Z