Relationship between 3'-azido-3'-deoxythymidine resistance and primer unblocking activity in foscarnet-resistant mutants of human immunodeficiency virus type 1 reverse transcriptase. - Wikidata - wikimedia - TriplyDB

Relationship between 3'-azido-3'-deoxythymidine resistance and primer unblocking activity in foscarnet-resistant mutants of human immunodeficiency virus type 1 reverse transcriptase.

Relationship between 3'-azido-3'-deoxythymidine resistance and primer unblocking activity in foscarnet-resistant mutants of human immunodeficiency virus type 1 reverse transcriptase.

http://www.wikidata.org/entity/Q34996622

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Role of helix P of the human cytomegalovirus DNA polymerase in resistance and hypersusceptibility to the antiviral drug foscarnet.Structural basis of HIV-1 resistance to AZT by excision Stable complexes formed by HIV-1 reverse transcriptase at distinct positions on the primer-template controlled by binding deoxynucleoside triphosphates or foscarnet Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance Purifying selection masks the mutational flexibility of HIV-1 reverse transcriptase.Kinetic pathway of pyrophosphorolysis by a retrotransposon reverse transcriptase.Interactions between HIV-1 reverse transcriptase and the downstream template strand in stable complexes with primer-template In vitro activity of structurally diverse nucleoside analogs against human immunodeficiency virus type 1 with the K65R mutation in reverse transcriptase The Role of Nucleotide Excision by Reverse Transcriptase in HIV Drug Resistance.Characterization of the polymerase and RNase H activities of human foamy virus reverse transcriptase.The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine.The K65R mutation in human immunodeficiency virus type 1 reverse transcriptase exhibits bidirectional phenotypic antagonism with thymidine analog mutations Involvement of novel human immunodeficiency virus type 1 reverse transcriptase mutations in the regulation of resistance to nucleoside inhibitors Inhibition of HIV-1 reverse transcription: basic principles of drug action and resistance.Utilization of a deoxynucleoside diphosphate substrate by HIV reverse transcriptase.DNA polymerases as therapeutic targets Thymidine analogue resistance suppression by V75I of HIV-1 reverse transcriptase: effects of substituting valine 75 on stavudine excision and discrimination.Effects of the Delta67 complex of mutations in human immunodeficiency virus type 1 reverse transcriptase on nucleoside analog excision.The pyrophosphate analogue foscarnet traps the pre-translocational state of HIV-1 reverse transcriptase in a Brownian ratchet model of polymerase translocation.Molecular determinants of multi-nucleoside analogue resistance in HIV-1 reverse transcriptases containing a dipeptide insertion in the fingers subdomain: effect of mutations D67N and T215Y on removal of thymidine nucleotide analogues from blocked DN Exploring the role of the α-carboxyphosphonate moiety in the HIV-RT activity of α-carboxy nucleoside phosphonates Chain-terminating dinucleoside tetraphosphates are substrates for DNA polymerization by human immunodeficiency virus type 1 reverse transcriptase with increased activity against thymidine analogue-resistant mutants.Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet.Foscarnet, zidovudine and dolutegravir combination efficacy and tolerability for late stage HIV salvage therapy: A case-series experience.In vitro human immunodeficiency virus type 1 resistance selections with combinations of tenofovir and emtricitabine or abacavir and lamivudine.Hypersusceptibility to substrate analogs conferred by mutations in human immunodeficiency virus type 1 reverse transcriptase.A role of template cleavage in reduced excision of chain-terminating nucleotides by human immunodeficiency virus type 1 reverse transcriptase containing the M184V mutation.Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase.Mechanism of resistance to GS-9148 conferred by the Q151L mutation in HIV-1 reverse transcriptase.Effects of primer-template sequence on ATP-dependent removal of chain-terminating nucleotide analogues by HIV-1 reverse transcriptase.The balance between NRTI discrimination and excision drives the susceptibility of HIV-1 RT mutants K65R, M184V and K65r+M184V.Conjugation of phosphonoacetic acid to nucleobase promotes a mechanism-based inhibition.Selective Excision of Chain-terminating Nucleotides by HIV-1 Reverse Transcriptase with Phosphonoformate as Substrate

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Relationship between 3'-azido-3'-deoxythymidine resistance and primer unblocking activity in foscarnet-resistant mutants of human immunodeficiency virus type 1 reverse transcriptase.

http://www.wikidata.org/entity/Q34996622

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2003 nî lūn-bûn

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2003 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2003年の論文

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2003年論文

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Relationship between 3'-azido- ...... type 1 reverse transcriptase.

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JVI.77.11.6127-6137.2003

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Journal of Virology

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Relationship between 3'-azido- ...... type 1 reverse transcriptase.

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Dianna Zonarich

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Eric Pendarvis

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Holly Z Bazmi

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John W Mellors

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Peter R Meyer

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Rahul R Chopra

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Suzanne E Matsuura

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Walter A Scott

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P2860

Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase

Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.

Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution

Functional characterization of RNA-dependent DNA polymerase and RNase H activities of a recombinant HIV reverse transcriptase

Isolation and characterization of a dideoxyguanosine triphosphate-resistant mutant of human immunodeficiency virus reverse transcriptase

Inhibition of human T-cell lymphotropic virus type III in vitro by phosphonoformate

Inhibition of HTLV-III/LAV replication by foscarnet

PPi analogs as inhibitors of human T-lymphotropic virus type III reverse transcriptase

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6127-6137

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10.1128/JVI.77.11.6127-6137.2003

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77

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2003-06-01T00:00:00Z

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12743270

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