Chromosomal and extrachromosomal localization of amplified dihydrofolate reductase genes in cultured mammalian cells.
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Evolutionary aspects of immunoglobulin heavy chain variable region (VH) gene subgroupsSimilar 150-kilobase DNA sequences are amplified in independently derived methotrexate-resistant Chinese hamster cells.Double minutes arise from circular extrachromosomal DNA intermediates which integrate into chromosomal sites in human HL-60 leukemia cells.Fifth Gordon Hamilton-Fairley memorial lecture. Methotrexate resistance and gene amplification: an experimental model for the generation of cellular heterogeneityResistance to cytostatic drugs at the cellular level.Gene amplification accompanies low level increases in the activity of dihydrofolate reductase in antifolate-resistant Chinese hamster lung cells containing abnormally banding chromosomes.Independent 5' and 3'-end determination of multiple dihydrofolate reductase transcripts.Construction and use of a dominant, selectable marker: a Harvey sarcoma virus-dihydrofolate reductase chimeraEvolution of chromosomal regions containing transfected and amplified dihydrofolate reductase sequences.Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyureaCo-amplification of double minute chromosomes, multiple drug resistance, and cell surface P-glycoprotein in DNA-mediated transformants of mouse cells.UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells.Relationship of amplified dihydrofolate reductase genes to double minute chromosomes in unstably resistant mouse fibroblast cell lines.Loss and stabilization of amplified dihydrofolate reductase genes in mouse sarcoma S-180 cell lines.Construction of a modular dihydrofolate reductase cDNA gene: analysis of signals utilized for efficient expressionCorrelation of unstable multidrug cross resistance in Chinese hamster ovary cells with a homogeneously staining region on chromosome 1.Elimination of extrachromosomally amplified MYC genes from human tumor cells reduces their tumorigenicity.Mitogenic hormones and tumor promoters greatly increase the incidence of colony-forming cells bearing amplified dihydrofolate reductase genes.Loss of unstably amplified dihydrofolate reductase genes from mouse cells is greatly accelerated by hydroxyureaOverproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica.Rapid spontaneous dihydrofolate reductase gene amplification shown by fluorescence-activated cell sortingUltrastructural features of minute chromosomes in a methotrexate-resistant mouse 3T3 cell linePenetrance and low concordance in monozygotic twins in disease: are they the results of alterations in somatic genomes?Methotrexate resistance and gene amplification. Mechanisms and implications.Meiotic drive in female mice: an essay.Drug-induced loss of unstably amplified genes.A clonal derivative of tunicamycin-resistant Chinese hamster ovary cells with increased N-acetylglucosamine-phosphate transferase activity has altered asparagine-linked glycosylation.Cytogenetic evaluation of human endothelial cell cultures.Cytological, flow cytometric, and molecular analysis of the rapid evolution of mammalian chromosomes containing highly amplified DNA sequences.
P2860
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P2860
Chromosomal and extrachromosomal localization of amplified dihydrofolate reductase genes in cultured mammalian cells.
description
1981 nî lūn-bûn
@nan
1981年の論文
@ja
1981年学术文章
@wuu
1981年学术文章
@zh-cn
1981年学术文章
@zh-hans
1981年学术文章
@zh-my
1981年学术文章
@zh-sg
1981年學術文章
@yue
1981年學術文章
@zh
1981年學術文章
@zh-hant
name
Chromosomal and extrachromosom ...... s in cultured mammalian cells.
@en
Chromosomal and extrachromosom ...... s in cultured mammalian cells.
@nl
type
label
Chromosomal and extrachromosom ...... s in cultured mammalian cells.
@en
Chromosomal and extrachromosom ...... s in cultured mammalian cells.
@nl
prefLabel
Chromosomal and extrachromosom ...... s in cultured mammalian cells.
@en
Chromosomal and extrachromosom ...... s in cultured mammalian cells.
@nl
P2093
P1476
Chromosomal and extrachromosom ...... s in cultured mammalian cells.
@en
P2093
P304
P356
10.1101/SQB.1981.045.01.097
P478
P577
1981-01-01T00:00:00Z