about
Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes.Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like SitesStructure-Based Design of β5c Selective Inhibitors of Human Constitutive ProteasomesEvidence of P-glycoprotein mediated apical to basolateral transport of flunisolide in human broncho-tracheal epithelial cells (Calu-3)Hydrophobic Interactions Contribute to Conformational Stabilization of Endoglycoceramidase II by Mechanism-Based Probes.Identification of an internalising peptide in differentiated Calu-3 cells by phage display technology; application to gene delivery to the airways.Nature of pharmacophore influences active site specificity of proteasome inhibitors.Activity-based probes for functional interrogation of retaining β-glucuronidases.Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5tA fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo.PABPN1-Dependent mRNA Processing Induces Muscle Wasting.Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment.Proteasome inhibitor-adapted myeloma cells are largely independent from proteasome activity and show complex proteomic changes, in particular in redox and energy metabolismActivity-based protein profiling: an enabling technology in chemical biology research.Toward understanding induction of oxidative stress and apoptosis by proteasome inhibitors.Tripeptidyl Peptidase II Mediates Levels of Nuclear Phosphorylated ERK1 and ERK2.Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons.Enantioselective synthesis of adamantylalanine and carboranylalanine and their incorporation into the proteasome inhibitor bortezomib.Activity-Based Protein Profiling: From Chemical Novelty to Biomedical Stalwart.Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases.Development and application of an in vitro apoptin kinase assay.Two-step bioorthogonal activity-based proteasome profiling using copper-free click reagents: a comparative study.Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib.Probing the proteasome cavity in three steps: bio-orthogonal photo-reactive suicide substrates.A cleavable linker based on the levulinoyl ester for activity-based protein profiling.Sugar amino acid based peptide epoxyketones as potential proteasome inhibitors.Syringolin A selectively labels the 20 S proteasome in murine EL4 and wild-type and bortezomib-adapted leukaemic cell lines.Mixing of peptides and electrophilic traps gives rise to potent, broad-spectrum proteasome inhibitors.Enhancement of bronchial octreotide absorption by chitosan and N-trimethyl chitosan shows linear in vitro/in vivo correlation.Transport and local metabolism of budesonide and fluticasone propionate in a human bronchial epithelial cell line (Calu-3).Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition.Stabilization of Glucocerebrosidase by Active Site Occupancy.Transfection efficiency and toxicity of polyethylenimine in differentiated Calu-3 and nondifferentiated COS-1 cell cultures.Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division.Correction to "Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes"Incorporation of fluorinated phenylalanine generates highly specific inhibitor of proteasome's chymotrypsin-like sites.Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS.Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-α in brain.Proteasomal activity-based probes mark protein homeostasis in muscles.
P50
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P50
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onderzoeker
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հետազոտող
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Bogdan I Florea
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Bogdan I Florea
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Bogdan I Florea
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Bogdan I Florea
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Bogdan I Florea
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Bogdan I Florea
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Bogdan I Florea
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Bogdan I Florea
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Bogdan I Florea
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Bogdan I Florea
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Bogdan I Florea
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Bogdan I Florea
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Bogdan I Florea
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Bogdan I Florea
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Bogdan I Florea
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P106
P108
P21
P31
P496
0000-0001-7114-2266