DNA topoisomerases in apicomplexan parasites: promising targets for drug discovery
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Mechanisms for Defining Supercoiling Set Point of DNA Gyrase Orthologs: II. THE SHAPE OF THE GyrA SUBUNIT C-TERMINAL DOMAIN (CTD) IS NOT A SOLE DETERMINANT FOR CONTROLLING SUPERCOILING EFFICIENCYReplacement of the human topoisomerase linker domain with the plasmodial counterpart renders the enzyme camptothecin resistantInvestigating the Roles of the C-Terminal Domain of Plasmodium falciparum GyrAComparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitorsTowards an immunosense vaccine to prevent toxoplasmosis: protective Toxoplasma gondii epitopes restricted by HLA-A*0201DNA topoisomerase II is involved in regulation of cyst wall protein genes and differentiation in Giardia lamblia.Plasmodium falciparum UvrD activities are downregulated by DNA-interacting compounds and its dsRNA inhibits malaria parasite growthPeptide Inhibition of Topoisomerase IB from Plasmodium falciparum.Unique features of apicoplast DNA gyrases from Toxoplasma gondii and Plasmodium falciparum.Toxoplasma gondii HLA-B*0702-restricted GRA7(20-28) peptide with adjuvants and a universal helper T cell epitope elicits CD8(+) T cells producing interferon-γ and reduces parasite burden in HLA-B*0702 miceMechanisms for defining supercoiling set point of DNA gyrase orthologs: I. A nonconserved acidic C-terminal tail modulates Escherichia coli gyrase activity.Functional Analyses of the Toxoplasma gondii DNA Gyrase Holoenzyme: A Janus Topoisomerase with Supercoiling and Decatenation Abilities.DNA-Binding and Topoisomerase-I-Suppressing Activities of Novel Vanadium Compound Van-7Droplet microfluidics platform for highly sensitive and quantitative detection of malaria-causing Plasmodium parasites based on enzyme activity measurement.Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discoveryIn vitro synergistic effect of fluoroquinolone analogues in combination with artemisinin against Plasmodium falciparum; their antiplasmodial action in rodent malaria model.Target-similarity search using Plasmodium falciparum proteome identifies approved drugs with anti-malarial activity and their possible targets.ATPase activity of Plasmodium falciparum MLH is inhibited by DNA-interacting ligands and dsRNAs of MLH along with UvrD curtail malaria parasite growth.Inhibitory effects of fluoroquinolone antibiotics on and , blood parasites of veterinary and zoonotic importance
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DNA topoisomerases in apicomplexan parasites: promising targets for drug discovery
description
im Juni 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published on 03 March 2010
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в червні 2010
@uk
name
DNA topoisomerases in apicomplexan parasites: promising targets for drug discovery
@en
DNA topoisomerases in apicomplexan parasites: promising targets for drug discovery
@nl
type
label
DNA topoisomerases in apicomplexan parasites: promising targets for drug discovery
@en
DNA topoisomerases in apicomplexan parasites: promising targets for drug discovery
@nl
prefLabel
DNA topoisomerases in apicomplexan parasites: promising targets for drug discovery
@en
DNA topoisomerases in apicomplexan parasites: promising targets for drug discovery
@nl
P2860
P50
P356
P1476
DNA topoisomerases in apicomplexan parasites: promising targets for drug discovery
@en
P2093
Christopher Fernández Prada
P2860
P304
P356
10.1098/RSPB.2009.2176
P407
P577
2010-03-03T00:00:00Z