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Human T cell aging and the impact of persistent viral infectionsConserved T cell receptor repertoire in primary and memory CD8 T cell responses to an acute viral infectionDelay of T cell senescence by caloric restriction in aged long-lived nonhuman primatesT-cell-mediated immunity and the role of TRAIL in sepsis-induced immunosuppressionHomeostasis and function of regulatory T cells in agingFunctionally Diverse NK-Like T Cells Are Effectors and Predictors of Successful AgingAgeing combines CD4 T cell lymphopenia in secondary lymphoid organs and T cell accumulation in gut associated lymphoid tissue.Effects of aging on the adaptive immune response to respiratory virus infections.Impact of ageing on the response and repertoire of influenza virus-specific CD4 T cells.Differences in the regulation of CD4 and CD8 T-cell clones during immune responses.The blood of healthy individuals exhibits CD8 T cells with a highly altered TCR Vb repertoire but with an unmodified phenotypeEvolution of the antigen-specific CD8+ TCR repertoire across the life span: evidence for clonal homogenization of the old TCR repertoire.Immune memory and aging: an infinite or finite resource?Nonmalignant clonal expansions of memory CD8+ T cells that arise with age vary in their capacity to mount recall responses to infection.Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories.Age-related dysregulation of CD8+ T cell memory specific for a persistent virus is independent of viral replicationInflation and long-term maintenance of CD8 T cells responding to a latent herpesvirus depend upon establishment of latency and presence of viral antigens.The narrowing of the CD8 T cell repertoire in old ageCytomegalovirus infection impairs immune responses and accentuates T-cell pool changes observed in mice with aging.Substituting threonine 187 with alanine in p27Kip1 prevents pituitary tumorigenesis by two-hit loss of Rb1 and enhances humoral immunity in old ageTripartite motif-containing protein 30 modulates TCR-activated proliferation and effector functions in CD4+ T cells.Chronic resveratrol intake reverses pro-inflammatory cytokine profile and oxidative DNA damage in ageing hybrid mice.T-cell biology in aging, with a focus on lung disease.CD8 T cell clonal expansions & aging: a heterogeneous phenomenon with a common outcomeDefective CD8 T cell responses in aged mice are due to quantitative and qualitative changes in virus-specific precursorsAging and CD8+ T cell immunity to respiratory virus infections.Dramatic increase in naive T cell turnover is linked to loss of naive T cells from old primates.Age and facial nerve axotomy-induced T cell trafficking: relation to microglial and motor neuron status.T cell receptor repertoire in polymyositis: clonal expansion of autoaggressive CD8+ T cells.Non-human primate models of T-cell reconstitution.Age-related CD8 T cell clonal expansions constrict CD8 T cell repertoire and have the potential to impair immune defense.Bone marrow microenvironmental changes underlie reduced RAG-mediated recombination and B cell generation in aged mice.Differential contributions of central and effector memory T cells to recall responses.Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates.A central role for thymic emigrants in peripheral T cell homeostasis.The repertoire of CD4+ CD28- T cells in rheumatoid arthritis.Differential effects of age on circulating and splenic leukocyte populations in C57BL/6 and BALB/c male mice.Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus.Ablation of thymic export causes accelerated decay of naive CD4 T cells in the periphery because of activation by environmental antigenIdentification of two major types of age-associated CD8 clonal expansions with highly divergent properties.
P2860
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P2860
description
im Dezember 1993 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published on 01 December 1993
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в грудні 1993
@uk
name
Unexpected expansions of CD8-bearing cells in old mice
@en
Unexpected expansions of CD8-bearing cells in old mice
@nl
type
label
Unexpected expansions of CD8-bearing cells in old mice
@en
Unexpected expansions of CD8-bearing cells in old mice
@nl
prefLabel
Unexpected expansions of CD8-bearing cells in old mice
@en
Unexpected expansions of CD8-bearing cells in old mice
@nl
P1476
Unexpected expansions of CD8-bearing cells in old mice
@en
P2093
Callahan JE
Kappler JW
P304
P407
P577
1993-12-01T00:00:00Z