Histone macroH2A isoforms predict the risk of lung cancer recurrence
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Immunopositivity for histone macroH2A1 isoforms marks steatosis-associated hepatocellular carcinomaThe histone variant macroH2A1 marks repressed autosomal chromatin, but protects a subset of its target genes from silencingATRX-mediated chromatin association of histone variant macroH2A1 regulates α-globin expressionThe atypical histone macroH2A1.2 interacts with HER-2 protein in cancer cellsMacro histone variants are critical for the differentiation of human pluripotent cellsChromatin Dynamics in Vivo: A Game of Musical ChairsEvery amino acid matters: essential contributions of histone variants to mammalian development and diseaseExpression and functionality of histone H2A variants in cancerMacroH2A histone variants act as a barrier upon reprogramming towards pluripotencySplicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasivenessHistone variants and epigenetics.Histone variant macroH2A confers resistance to nuclear reprogramming.Histone variants: emerging players in cancer biology.Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells.Increased macroH2A1.1 expression correlates with poor survival of triple-negative breast cancer patientsThe histone variant MacroH2A1 regulates target gene expression in part by recruiting the transcriptional coregulator PELP1.The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes.Overexpression of histone variant H2A.1 and cellular transformation are related in N-nitrosodiethylamine-induced sequential hepatocarcinogenesis.The histone H2A variant macroH2A1 does not localize to the centrosome.Histone H2A.Z deregulation in prostate cancer. Cause or effect?A macrohistone variant links dynamic chromatin compaction to BRCA1-dependent genome maintenance.QKI-mediated alternative splicing of the histone variant MacroH2A1 regulates cancer cell proliferationGenome-wide distribution of macroH2A1 histone variants in mouse liver chromatin.MacroH2A1.1 and PARP-1 cooperate to regulate transcription by promoting CBP-mediated H2B acetylation.Mice without macroH2A histone variants.Synergism between DNA methylation and macroH2A1 occupancy in epigenetic silencing of the tumor suppressor gene p16(CDKN2A).The histone variant macroH2A suppresses melanoma progression through regulation of CDK8.The transcriptional cofactor MCAF1/ATF7IP is involved in histone gene expression and cellular senescenceRole of ATRX in chromatin structure and function: implications for chromosome instability and human diseaseSkp2-macroH2A1-CDK8 axis orchestrates G2/M transition and tumorigenesis.The nonhistone, N-terminal tail of an essential, chimeric H2A variant regulates mitotic H3-S10 dephosphorylation.MacroH2A1 regulates the balance between self-renewal and differentiation commitment in embryonic and adult stem cells.Epigenetic stability of repressed states involving the histone variant macroH2A revealed by nuclear transfer to Xenopus oocytes.MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory PhenotypePhosphorylated fraction of H2AX as a measurement for DNA damage in cancer cells and potential applications of a novel assayThe right place at the right time: chaperoning core histone variantsHistone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency.MacroH2A1 downregulation enhances the stem-like properties of bladder cancer cells by transactivation of Lin28BDifferential regulation and predictive potential of MacroH2A1 isoforms in colon cancer.Loss of histone variant macroH2A2 expression associates with progression of anal neoplasm.
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Histone macroH2A isoforms predict the risk of lung cancer recurrence
description
im August 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published on 03 August 2009
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в серпні 2009
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name
Histone macroH2A isoforms predict the risk of lung cancer recurrence
@en
Histone macroH2A isoforms predict the risk of lung cancer recurrence
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type
label
Histone macroH2A isoforms predict the risk of lung cancer recurrence
@en
Histone macroH2A isoforms predict the risk of lung cancer recurrence
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prefLabel
Histone macroH2A isoforms predict the risk of lung cancer recurrence
@en
Histone macroH2A isoforms predict the risk of lung cancer recurrence
@nl
P2093
P2860
P50
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P1476
Histone macroH2A isoforms predict the risk of lung cancer recurrence
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P2093
P2860
P2888
P304
P356
10.1038/ONC.2009.26
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P577
2009-08-03T00:00:00Z