Congenital nephrotic syndrome in mice lacking CD2-associated protein
about
Podocin localizes in the kidney to the slit diaphragm areaMutations in the gene that encodes the F-actin binding protein anillin cause FSGSCIN85 regulates dopamine receptor endocytosis and governs behaviour in miceIQGAP1 interacts with components of the slit diaphragm complex in podocytes and is involved in podocyte migration and permeability in vitroClues to CD2-associated protein involvement in cytokinesisPodocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrinLoss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeletonGenotype-phenotype correlations in non-Finnish congenital nephrotic syndromeNegative regulation of PI 3-kinase by Ruk, a novel adaptor proteinCo-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formationNeph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeabilityNephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrinAnuria, omphalocele, and perinatal lethality in mice lacking the CD34-related protein podocalyxinIn vivo expression of putative LMX1B targets in nail-patella syndrome kidneysAlpha-actinin-4-mediated FSGS: an inherited kidney disease caused by an aggregated and rapidly degraded cytoskeletal proteinPodocytesRole of Neuropilin-1 in Diabetic NephropathyRoles of adaptor proteins in podocyte biologyThe Rac1 hypervariable region in targeting and signaling: a tail of many storiesGenes and podocytes - new insights into mechanisms of podocytopathyCapping protein regulators fine-tune actin assembly dynamicsPodocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress ResponseThe structural and functional organization of the podocyte filtration slits is regulated by Tjp1/ZO-1Translating genetic findings in hereditary nephrotic syndrome: the missing loopsInvolvement of lipid rafts in nephrin phosphorylation and organization of the glomerular slit diaphragmNephrin redistribution on podocytes is a potential mechanism for proteinuria in patients with primary acquired nephrotic syndromeAltered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rateProteinuria precedes podocyte abnormalities inLamb2-/- mice, implicating the glomerular basement membrane as an albumin barrierCell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complexCD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survivalSlit diaphragms contain tight junction proteinsLarge-scale identification of genes implicated in kidney glomerulus development and function.TM4SF10 and ADAP interaction in podocytes: role in Fyn activity and nephrin phosphorylationMice deficient in alpha-actinin-4 have severe glomerular diseaseNeph1 cooperates with nephrin to transduce a signal that induces actin polymerizationNephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signalingDifferential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3).Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model.Structure of the kidney slit diaphragm adapter protein CD2-associated protein as determined with electron microscopy.Rac1 recruits the adapter protein CMS/CD2AP to cell-cell contacts.
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Congenital nephrotic syndrome in mice lacking CD2-associated protein
description
article publié dans la revue scientifique Science
@fr
im Oktober 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Science
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в жовтні 1999
@uk
name
Congenital nephrotic syndrome in mice lacking CD2-associated protein
@en
Congenital nephrotic syndrome in mice lacking CD2-associated protein
@nl
type
label
Congenital nephrotic syndrome in mice lacking CD2-associated protein
@en
Congenital nephrotic syndrome in mice lacking CD2-associated protein
@nl
prefLabel
Congenital nephrotic syndrome in mice lacking CD2-associated protein
@en
Congenital nephrotic syndrome in mice lacking CD2-associated protein
@nl
P2093
P1433
P1476
Congenital nephrotic syndrome in mice lacking CD2-associated protein
@en
P2093
O Kanagawa
V Karpitskii
P304
P356
10.1126/SCIENCE.286.5438.312
P407
P577
1999-10-01T00:00:00Z