ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma
about
STAT3 protein up-regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasisDifferential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasionRho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapyIntravital imaging reveals new ancillary mechanisms co-opted by cancer cells to drive tumor progressionRho, ROCK and actomyosin contractility in metastasis as drug targetsRho-associated kinase signalling and the cancer microenvironment: novel biological implications and therapeutic opportunitiesRho GTPase signalling in cell migrationEpithelia migration: a spatiotemporal interplay between contraction and adhesionAt the leading edge of three-dimensional cell migrationMatrikine and matricellular regulators of EGF receptor signaling on cancer cell migration and invasionCollective cell migrationsRegulation of ROCK activity in cancerApolar and polar transitions drive the conversion between amoeboid and mesenchymal shapes in melanoma cells.Intravital imaging of SRF and Notch signalling identifies a key role for EZH2 in invasive melanoma cellsTumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces.Trkb signaling in pericytes is required for cardiac microvessel stabilizationStromal fibroblasts mediate extracellular matrix remodeling and invasion of scirrhous gastric carcinoma cellsCell cycle-dependent Rho GTPase activity dynamically regulates cancer cell motility and invasion in vivoSH3-domain binding protein 1 in the tumor microenvironment promotes hepatocellular carcinoma metastasis through WAVE2 pathwayRoles of paxillin family members in adhesion and ECM degradation coupling at invadosomesTumor microenvironment complexity: emerging roles in cancer therapy.FilGAP, a Rho/Rho-associated protein kinase-regulated GTPase-activating protein for Rac, controls tumor cell migrationGenotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.Loss of ERα induces amoeboid-like migration of breast cancer cells by downregulating vinculin.Mesenchymal to amoeboid transition is associated with stem-like features of melanoma cells.Migrastatics-Anti-metastatic and Anti-invasion Drugs: Promises and Challenges.Fibroblast heterogeneity in the cancer wound.Diverse matrix metalloproteinase functions regulate cancer amoeboid migrationTumour cells expressing single VEGF isoforms display distinct growth, survival and migration characteristicsCell-based and in vivo spectral analysis of fluorescent proteins for multiphoton microscopy.Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism.ROCK1 is a potential combinatorial drug target for BRAF mutant melanomaSystem-wide analysis reveals a complex network of tumor-fibroblast interactions involved in tumorigenicityThe microRNA-130/301 family controls vasoconstriction in pulmonary hypertensionLPA Induces Colon Cancer Cell Proliferation through a Cooperation between the ROCK and STAT-3 Pathways.Soft fibrin gels promote selection and growth of tumorigenic cells.The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment.Multifaceted tumor stromal fibroblastsTGF-β-Induced Transcription Sustains Amoeboid Melanoma Migration and Dissemination.Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts
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ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma
description
im August 2011 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published on 01 August 2011
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в серпні 2011
@uk
name
ROCK and JAK1 Signaling Cooper ...... lity in Tumor Cells and Stroma
@en
ROCK and JAK1 Signaling Cooper ...... lity in Tumor Cells and Stroma
@nl
type
label
ROCK and JAK1 Signaling Cooper ...... lity in Tumor Cells and Stroma
@en
ROCK and JAK1 Signaling Cooper ...... lity in Tumor Cells and Stroma
@nl
prefLabel
ROCK and JAK1 Signaling Cooper ...... lity in Tumor Cells and Stroma
@en
ROCK and JAK1 Signaling Cooper ...... lity in Tumor Cells and Stroma
@nl
P2093
P50
P1433
P1476
ROCK and JAK1 signaling cooper ...... lity in tumor cells and stroma
@en
P2093
Amaya Viros
Chris J Marshall
Fredrik Wallberg
James Larkin
Jean Albrengues
Maggie Yeo
Martin Cook
Steven Hooper
Victoria Sanz-Moreno
P304
P356
10.1016/J.CCR.2011.06.018
P577
2011-08-01T00:00:00Z