Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinasein Vivoat Thr-412 as well as Thr-252
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The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activityIdentification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKATime-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1Regulation of ribosomal S6 kinase 2 by effectors of the phosphoinositide 3-kinase pathwayA 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1Salicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-myc, cyclin D1, cyclin A, and proliferating cell nuclear antigenInhibition of insulin-induced activation of Akt by a kinase-deficient mutant of the epsilon isozyme of protein kinase CRegulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation sitePhosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowthMolecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivoMembrane localization of 3-phosphoinositide-dependent protein kinase-1 stimulates activities of Akt and atypical protein kinase C but does not stimulate glucose transport and glycogen synthesis in 3T3-L1 adipocytes.Regulation of glycogen synthesis by amino acids in cultured human muscle cells.Modulation of cyclin D1 and its signaling components by the phorbol ester TPA and the tyrosine phosphatase inhibitor vanadate.PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle.Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulationNDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling.Nicotine inhibits memory CTL programmingEffects of a brief high-fat diet and acute exercise on the mTORC1 and IKK/NF-κB pathways in rat skeletal muscleMechanism of PDK1-catalyzed Thr-229 phosphorylation of the S6K1 protein kinase.Phospho-p70S6K and cdc2/cdk1 as therapeutic targets for diffuse large B-cell lymphoma.Mammalian TOR signaling to the AGC kinases.p70 S6 kinase and actin dynamics: A perspective.Exploiting p70 S6 kinase as a target for ovarian cancer.Conditional and domain-specific inactivation of the Tsc2 gene in neural progenitor cells.Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding.Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons.Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells.The Rb-family protein p107 inhibits translation by a PDK1-dependent mechanism.Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1.Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line.A new role for the p85-phosphatidylinositol 3-kinase regulatory subunit linking FRAP to p70 S6 kinase activation.Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation.Role of PDK1 in insulin-signaling pathway for glucose metabolism in 3T3-L1 adipocytes.Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity.Signal pathways involved in activation of p70S6K and phosphorylation of 4E-BP1 following exposure of multiple myeloma tumor cells to interleukin-6.Signalling pathways and combinatory effects of insulin and amino acids in isolated rat hepatocytes.Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue.IGF-I elicits growth of human intestinal smooth muscle cells by activation of PI3K, PDK-1, and p70S6 kinase.Mitotic regulation of ribosomal S6 kinase 1 involves Ser/Thr, Pro phosphorylation of consensus and non-consensus sites by Cdc2.
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P2860
Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinasein Vivoat Thr-412 as well as Thr-252
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im Dezember 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в грудні 1999
@uk
name
Evidence That 3-Phosphoinositi ...... oat Thr-412 as well as Thr-252
@en
Evidence That 3-Phosphoinositi ...... oat Thr-412 as well as Thr-252
@nl
type
label
Evidence That 3-Phosphoinositi ...... oat Thr-412 as well as Thr-252
@en
Evidence That 3-Phosphoinositi ...... oat Thr-412 as well as Thr-252
@nl
prefLabel
Evidence That 3-Phosphoinositi ...... oat Thr-412 as well as Thr-252
@en
Evidence That 3-Phosphoinositi ...... oat Thr-412 as well as Thr-252
@nl
P2093
P2860
P356
P1476
Evidence that 3-phosphoinositi ...... at Thr-412 as well as Thr-252
@en
P2093
A Balendran
C G Armstrong
P2860
P304
37400-37406
P356
10.1074/JBC.274.52.37400
P407
P577
1999-12-01T00:00:00Z