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Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich regionRestricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathwaysFunctional interaction between RAFT1/FRAP/mTOR and protein kinase cdelta in the regulation of cap-dependent initiation of translationRegulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathwayRegulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinaseCloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); a novel nuclear target of AktSalicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-myc, cyclin D1, cyclin A, and proliferating cell nuclear antigenRegulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation siteThe p70S6K Specific Inhibitor PF-4708671 Impedes Non-Small Cell Lung Cancer GrowthRibosomal protein S6 phosphorylation and function during late gestation liver development in the ratGlucocorticoids modulate amino acid-induced translation initiation in human skeletal muscle.Integrin-dependent activation of the p70 ribosomal S6 kinase signaling pathway.Differential activation of p70 and p85 S6 kinase isoforms during cardiac hypertrophy in the adult mammal.High-frequency electrically stimulated skeletal muscle contractions increase p70s6k phosphorylation independent of known IGF-I sensitive signaling pathways4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle.Role of MLK3-mediated activation of p70 S6 kinase in Rac1 transformation.The phosphorylated ribosomal protein S7 in Tetrahymena is homologous with mammalian S4 and the phosphorylated residues are located in the C-terminal region. Structural characterization of proteins separated by two-dimensional polyacrylamide gel elecThe modular phosphorylation and activation of p70s6k.Cellular signalling pathways: new targets in leukaemia therapy.Increase of microRNA-210, decrease of raptor gene expression and alteration of mammalian target of rapamycin regulated proteins following mithramycin treatment of human erythroid cells.A Drosophila gene structurally and functionally homologous to the mammalian 70-kDa s6 kinase gene.Estrogenic regulation of S6K1 expression creates a positive regulatory loop in control of breast cancer cell proliferationTargeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity.The role of S6K1 in ER-positive breast cancer.Overexpression of P70 S6 kinase protein is associated with increased risk of locoregional recurrence in node-negative premenopausal early breast cancer patients.Phospho-p70S6K and cdc2/cdk1 as therapeutic targets for diffuse large B-cell lymphoma.p70 S6 kinase and actin dynamics: A perspective.Hypoxia-induced nitric oxide production and tumour perfusion is inhibited by pegylated arginine deiminase (ADI-PEG20).4E-BP1 regulates the sensitivity of human glioma cells to chemotherapy through PI3K/Akt/mTOR-independent pathway.hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase.S6 phosphorylation and the p70s6k/p85s6k.Rapamycin induces the fusion-type independent downregulation of the EWS/FLI-1 proteins and inhibits Ewing's sarcoma cell proliferation.Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma.Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling.A new role for the p85-phosphatidylinositol 3-kinase regulatory subunit linking FRAP to p70 S6 kinase activation.The carboxyl-terminal domain of the granulocyte colony-stimulating factor receptor uncouples ribosomal biogenesis from cell cycle progression in differentiating 32D myeloid cells.A study of death by anoikis in cultured epithelial cells.Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation.Constitutive PI3-K activity is essential for proliferation, but not survival, of Theileria parva-transformed B cells.Farnesyltransferase inhibitor induces rapid growth arrest and blocks p70s6k activation by multiple stimuli.
P2860
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P2860
description
article publié dans la revue scientifique Nature
@fr
scientific article published in Nature
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в Nature в травні 1993
@uk
name
p70s6k function is essential for G1 progression
@en
p70s6k function is essential for G1 progression
@nl
type
label
p70s6k function is essential for G1 progression
@en
p70s6k function is essential for G1 progression
@nl
prefLabel
p70s6k function is essential for G1 progression
@en
p70s6k function is essential for G1 progression
@nl
P2093
P356
P1433
P1476
p70s6k function is essential for G1 progression
@en
P2093
P2888
P304
P356
10.1038/363170A0
P407
P577
1993-05-01T00:00:00Z
P6179
1051109433